Consequences of myocardial reperfusion following temporary coronary occlusion in pigs: effects on morphologic, biochemical and haemodynamic findings

Althaus, U; Gurtner, H. P.; Baur, H; Hamburger, Steven A.; Roos, Bernard A.

doi:10.1111/j.1365-2362.1977.tb01631.x

Cited by 50 publications

(4 citation statements)

References 28 publications

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“…Furthermore, delayed reperfusion may improve the rate and extent of infarct healing. 62 Thrombolytic therapy offers an attractive rapid method of establishing reperfusion in patients with cardiogenic shock. However, Mathey et al63, 64 and Rentrop et a165 have demonstrated low rates of recanalization in shock patients with intracoronary streptokinase and no improvement in mortality over conventional therapy.…”

Section: Discussionmentioning

confidence: 99%

Percutaneous transluminal coronary angioplasty improves survival in acute myocardial infarction complicated by cardiogenic shock.

et al. 1988

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Modest survival benefits have been reported in patients with acute myocardial infarction complicated by cardiogenic shock who were treated with early surgical revascularization or thrombolytic therapy. To determine whether coronary angioplasty improves survival, 87 patients with cardiogenic shock complicating acute myocardial infarction at the University of Michigan, Ann Arbor, Michigan, from 1975 to 1985 were retrospectively analyzed. Patients in group 1 (n= 59) were treated with conventional therapy; patients in group 2 (n=24) were treated with conventional therapy and angioplasty. Extent of coronary artery disease, infarct location, and incidence of multivessel disease were similar between groups. Hemodynamic variables including cardiac index, mean arterial pressure, and pulmonary capillary wedge pressure were also similar. The 30-day survival was significantly improved for group 2 patients (50% vs. 17%, p=0.006). Survival in group 2 patients with successful angioplasty was 77% (10 of 13 patients) versus 18% (two of 11 patients) in patients with unsuccessful angioplasty, (p=0.006). The findings suggest that angioplasty improves survival in cardiogenic shock compared with conventional therapy with survival contingent upon successful reperfusion of the infarct-related artery. (Circulation 1988;78:1345-1351 C ardiogenic shock remains a lethal complication of acute myocardial infarction.

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Section: Discussionmentioning

confidence: 99%

Percutaneous transluminal coronary angioplasty improves survival in acute myocardial infarction complicated by cardiogenic shock.

et al. 1988

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“…Reperfusion has previously been implicated in altering the healing process after myocardial infarction by affecting granulation tissue formation (Rona and Kahn, 1969;Althaus et al, 1977;Shetlar et al, 1979;Roberts et al, 1983). However, Fishbein and associates (1981) found that reperfusion had no effect on wall thickness, hemorrhage, granulation tissue formation, or inflammation at 1 week.…”

mentioning

confidence: 99%

“…Reperfusion has also been associated with changes in the occurrence of aneurysm. Althaus et al (1977) found a decreased incidence of aneurysmal dilation with 575 reperfusion, while Rona and Kahn (1969) found an increased incidence of aneurysm in their perfused infarcts.…”

mentioning

confidence: 99%

Effects of reperfusion after coronary artery occlusion on post-infarction scar tissue.

Connelly¹,

Vogel²,

Wiegner³

et al. 1985

Circulation Research

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SUMMARY. Early reperfusion after a coronary occlusion may reduce myocardial infarct size, but late reperfusion into necrotic myocardium may alter post-infarction healing. In rabbits, we compared 1-or 3-week-old scars resulting from permanent coronary occlusion to those resulting from a 1-or 3-hour occlusion followed by reperfusion. Reperfusion at 1 hour post-occlusion did not affect scar mechanical properties assessed at 1 week post-infarction, but at 3 weeks postinfarction, these scars had a tensile strength significantly lower than those not reperfused (78 ± 11 vs. 158 ± 15 g/mm 2 , P < 0.001). They also were composed of a mixture of fibrous tissue (58 ± 8%) and myocytes (43 ± 8%) with a hydroxyproline content of 23 ± 2.5 mg/g dry weight. The nonreperfused scars had a higher proportion of fibrous tissue (73 ± 3%) by histological evaluation and a 35% higher hydroxyproline content (31 ± 2 mg/g dry weight, P < 0.001) than the scars reperfused after 1 hour. In contrast, 3-week-old scars resulting from late' reperfusion at 3 hours post-occlusion were similar to nonreperfused scars in fibrous tissue composition and hydroxyproline content. Nonetheless, the tensile strength of these scars reperfused 3 hours post-occlusion was significantly less than that of the nonreperfused scars (72 ± 5 vs. 158 ± 15 g/mm 2 , P < 0.001). The lower tensile strength was associated with a lower collagen cross-link density in this reperfused group of scars. At physiological stress levels (approximately 3 g/mm 2 ), all groups of reperfused and nonreperfused scars had similar mechanical properties in terms of natural strain, stiffness, creep, and stress relaxation. Thus, although the reperfused scars ruptured more easily at high stresses, when assessed at physiological stresses their mechanical properties were not significantly different from those of nonreperfused scars. (Circ Res 57: 562-577, 1985)

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“…In our study only one hemorrhagic infarct was detected by histology. In the pig (30) and in the dog (31) hemorrhage has been recorded following reperfusion. Hemorrhage would increase the tissue water content and therefore give rise to contrast in NMR images.…”

Section: Discussionmentioning

confidence: 99%

Detection of myocardial infarction in the mini‐pig using NMR imaging

Checkley¹,

Loveday²,

Waterton³

et al. 1987

Magnetic Resonance in Med

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Spin-echo images of 10 myocardial infarcts in nine mini-pigs were obtained at 30 h, 3 days, and approximately 10 days postinfarction. Infarcts were not detected at all at 30 h in five out of five cases examined. At 3 days postembolization (six cases) one infarct was certainly detected, whilst at 10 days (nine cases) all infarcts were seen as high-signal areas in long TE spin-echo sequences. After 2 weeks no further infarct signal change was detected (three cases), but myocardial thinning became more evident. Using techniques similar to those reported here, early postinfarct changes in the dog have been detected by other authors. Possible reasons for this difference between pig and dog are discussed.

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Consequences of myocardial reperfusion following temporary coronary occlusion in pigs: effects on morphologic, biochemical and haemodynamic findings

Cited by 50 publications

References 28 publications

Percutaneous transluminal coronary angioplasty improves survival in acute myocardial infarction complicated by cardiogenic shock.

Percutaneous transluminal coronary angioplasty improves survival in acute myocardial infarction complicated by cardiogenic shock.

Effects of reperfusion after coronary artery occlusion on post-infarction scar tissue.

Detection of myocardial infarction in the mini‐pig using NMR imaging

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