Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
ObjectiveWe linked pharmacy dispensing data to clinical data in the electronic health record (EHR) to 1) identify characteristics associated with adherence to methotrexate (MTX) and 2) determine the association between adherence and disease activity in patients with JIA.MethodsWe conducted a single‐center retrospective cohort study of incident MTX users with JIA treated between 1/2016 and 9/2023 for ≥12 months. Using pharmacy dispensing data, complemented by EHR data, we estimated adherence using medication possession ratios (MPRs) over the first 365‐days of treatment. We used Fisher's exact and Wilcoxon rank‐sum tests to compare patient characteristics between adherent (MPR≥80%) and nonadherent (MPR<80%) groups and multivariable linear regression to investigate associations between MPR and active joint count.ResultsAmong 224 patients, 81 (36.2%) were classified as nonadherent. In bivariate analysis, patients of younger age, Black race, and from areas with lower child opportunity index (COI) were more likely to be classified as nonadherent. In multivariable analysis, active joint count changed from baseline to 12‐month follow‐up by ‐0.38 joints in the adherent compared to nonadherent group (95% CI ‐0.74,‐0.01) and by ‐1.18 joints in patients with polyarticular course (95% CI ‐2.23,‐0.13).ConclusionLinking dispense data to clinical EHR data offers a novel, objective method for evaluating adherence to chronic medications. We identified demographic and area‐level determinants of adherence, along with small but statistically significant differences in JIA disease activity measures by adherence status. Future work is needed to evaluate adherence as a potential mediator of known outcome disparities for socially disadvantaged populations.
ObjectiveWe linked pharmacy dispensing data to clinical data in the electronic health record (EHR) to 1) identify characteristics associated with adherence to methotrexate (MTX) and 2) determine the association between adherence and disease activity in patients with JIA.MethodsWe conducted a single‐center retrospective cohort study of incident MTX users with JIA treated between 1/2016 and 9/2023 for ≥12 months. Using pharmacy dispensing data, complemented by EHR data, we estimated adherence using medication possession ratios (MPRs) over the first 365‐days of treatment. We used Fisher's exact and Wilcoxon rank‐sum tests to compare patient characteristics between adherent (MPR≥80%) and nonadherent (MPR<80%) groups and multivariable linear regression to investigate associations between MPR and active joint count.ResultsAmong 224 patients, 81 (36.2%) were classified as nonadherent. In bivariate analysis, patients of younger age, Black race, and from areas with lower child opportunity index (COI) were more likely to be classified as nonadherent. In multivariable analysis, active joint count changed from baseline to 12‐month follow‐up by ‐0.38 joints in the adherent compared to nonadherent group (95% CI ‐0.74,‐0.01) and by ‐1.18 joints in patients with polyarticular course (95% CI ‐2.23,‐0.13).ConclusionLinking dispense data to clinical EHR data offers a novel, objective method for evaluating adherence to chronic medications. We identified demographic and area‐level determinants of adherence, along with small but statistically significant differences in JIA disease activity measures by adherence status. Future work is needed to evaluate adherence as a potential mediator of known outcome disparities for socially disadvantaged populations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.