Consequences of the Use of Anabolic-Androgenic Steroids for Male Athletes’ Fertility

García-Manso, Juan Manuel; Valverde-Esteve, Teresa

doi:10.1007/978-1-4939-3402-7_10

Cited by 2 publications

(3 citation statements)

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“…An impairment of the blood-testis-barrier was also observed in CD1 mice treated with ND, which may play a role in triggering the spermatogenesis alteration [ 103 ]. Moreover, quantitative changes in number, diameter and thickness of seminiferous tubules were detected in albino rats after AAS administration [ 104 ]. Apoptosis has been reported to play an important role in the regulation of germ cell populations in the adult testes.…”

Section: Aas Use and Adverse Effectsmentioning

confidence: 99%

“…The incidence of AASs in protamine and DNA fragmentation is a relevant issue in the study of male fertility, given that these drugs are used in high doses as in the case of some athletes. In addition, a direct relationship between irregular protamine expression and sperm count, motility, morphology, or fertilization was reported [ 104 ].…”

Section: Aas Use and Adverse Effectsmentioning

confidence: 99%

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Adverse Effects of Anabolic-Androgenic Steroids: A Literature Review

et al. 2021

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Anabolic-androgenic steroids (AASs) are a large group of molecules including endogenously produced androgens, such as testosterone, as well as synthetically manufactured derivatives. AAS use is widespread due to their ability to improve muscle growth for aesthetic purposes and athletes’ performance, minimizing androgenic effects. AAS use is very popular and 1–3% of US inhabitants have been estimated to be AAS users. However, AASs have side effects, involving all organs, tissues and body functions, especially long-term toxicity involving the cardiovascular system and the reproductive system, thereby, their abuse is considered a public health issue. The aim of the proposed review is to highlight the most recent evidence regarding the mechanisms of action of AASs and their unwanted effects on organs and lifestyle, as well as suggesting that AAS misuse and abuse lead to adverse effects in all body tissues and organs. Oxidative stress, apoptosis, and protein synthesis alteration are common mechanisms involved in AAS-related damage in the whole body. The cardiovascular system and the reproductive system are the most frequently involved apparatuses. Epidemiology as well as the molecular and pathological mechanisms involved in the neuropsychiatric side-effects of AAS abuse are still unclear, further research is needed in this field. In addition, diagnostically reliable tests for AAS abuse should be standardized. In this regard, to prevent the use of AASs, public health measures in all settings are crucial. These measures consist of improved knowledge among healthcare workers, proper doping screening tests, educational interventions, and updated legislation.

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Section: Aas Use and Adverse Effectsmentioning

confidence: 99%

Section: Aas Use and Adverse Effectsmentioning

confidence: 99%

Adverse Effects of Anabolic-Androgenic Steroids: A Literature Review

et al. 2021

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“…Even if rare, endocrine diseases should be closely related to nc-SD. Notably, when other causes are excluded, this tragic event may be related to different pathological statuses such as adrenal insufficiency (although infrequent, it may occur in individuals treated for other critical conditions where impairment of corticoadrenal function often happen) [98,99], diabetic coma [100], severe hypothyroidism (myxedema) [101], parathyroid crisis [102,103], thymoma [104], etc.…”

Section: Endocrine Systemmentioning

confidence: 99%

Forensic Science and Legal Medicine

2022

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Consequences of the Use of Anabolic-Androgenic Steroids for Male Athletes’ Fertility

Cited by 2 publications

References 95 publications

Adverse Effects of Anabolic-Androgenic Steroids: A Literature Review

Adverse Effects of Anabolic-Androgenic Steroids: A Literature Review

Forensic Science and Legal Medicine

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