Consequences of unilateral hearing loss: Time dependent regulation of protein synthesis in auditory brainstem nuclei

Hutson, Kendall A.; Durham, Dianne; Tucci, Debara L.

doi:10.1016/j.heares.2007.08.003

Cited by 16 publications

(17 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our previous studies, including recent evidence demonstrating the effect of CHL on protein synthesis in the MSO [Tucci et al, 1999;Hutson et al, 2007], suggest that a unilateral CHL has a particularly rapid effect on the MSO. Our 2-DG studies show that 48 h after CHL, the level of activity in the ipsilateral MSO was lower than that in the contralateral MSO, while after 3 weeks the levels in each MSO were the same.…”

Section: Central Effects Of Unilateral Chlmentioning

confidence: 79%

Reversible Conductive Hearing Loss: Restored Activity in the Central Auditory System

2008

Self Cite

View full text Add to dashboard Cite

The effect of a reversible, unilateral hearing loss on 2-deoxyglucose (2-DG) uptake in the central auditory system was studied using young gerbils. All animals had a unilateral conductive hearing loss (CHL), induced by atresia, on postnatal day 21 (P21). One week later, on P28, animals had their atresia repaired (CHL/R), or not repaired (CHL/NR), and CHL/NR animals entered the 2-DG experiments. CHL/R animals were allowed a 1-week period of restored binaural hearing experience prior to entering 2-DG experiments on P35. Animals in each group were injected with 2-DG and exposed to ambient sounds for 45 min prior to sacrifice. Uptake of 2-DG was measured in the anteroventral cochlear nucleus (AVCN), the medial superior olive (MSO), and the inferior colliculus (IC) on both sides of the brain. In CHL/NR animals, there were significant differences in uptake between the AVCN, MSO, and IC ipsilateral versus contralateral to the manipulated ear, indicating an imbalance in ascending afferent activity. In CHL/R animals, there were no significant differences, suggesting that 1 week after CHL repair, the appearance of balanced afferent activity had been restored.

show abstract

Section: Central Effects Of Unilateral Chlmentioning

confidence: 79%

Reversible Conductive Hearing Loss: Restored Activity in the Central Auditory System

2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…MCHL alters the cellular metabolism and protein synthesis in cells of the cochlear nucleus of the contralateral side (Tucci et al, 1999; Hutson et al, 2007). In this study, we observed that BCs and FCs on the side contralateral to the earplug altered their general expression of GluA3 (up) and GlyRα1 (down) in response to 1 week of MCHL.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, MCHL alters the metabolism and synthesis of proteins in central auditory system structures (Tucci et al, 1999; Hutson et al, 2007). The extent of such alterations depends on the duration, experimental procedure, and animal age (Tucci et al, 1999; Hutson et al, 2007). …”

Section: Introductionmentioning

confidence: 99%

Monaural conductive hearing loss alters the expression of the GluA3 AMPA and glycine receptor α1 subunits in bushy and fusiform cells of the cochlear nucleus

et al. 2011

View full text Add to dashboard Cite

The impact of conductive hearing loss (CHL), the second most common form of hearing loss, on neuronal plasticity in the central auditory pathway is unknown. After short-term (1 day) monaural earplugging, the GluA3 subunits of the AMPA receptor (AMPAR) are upregulated at auditory nerve synapses on the projection neurons of the cochlear nucleus; glycine receptor α1 (GlyRα1) subunits are downregulated at inhibitory synapses in the same neuronal population. These data suggest that CHL affects receptor trafficking at synapses. We examined the impact of 7 days of CHL on the general expression of excitatory and inhibitory receptors by quantitative biochemistry and immunohistochemistry, using specific antibodies to detect AMPAR subunits (GluA1, GluA2, GluA2/3, and GluA4), GlyRα1, and the GABAA receptor subunit β2/3. Following monaural earplugging and an elevation of the hearing threshold by approximately 35 dB, the immunolabeling of the antibody for the GluA2/3 subunits but not the GluA2 subunit increased on bushy cells (BCs) and fusiform cells (FCs) of the ipsilateral ventral and dorsal cochlear nuclei. These same cell types showed a downregulation of the GlyRα1 subunit. Similar results were observed in the contralateral nuclei. The expression levels of GABAA β2/3 were unchanged. These findings suggest that, following longer periods of monaural conductive hearing loss, the synthesis and subsequent composition of specific glutamate and glycine receptors in projection neurons and their synapses are altered; these changes may contribute to abnormal auditory processing.

show abstract

“…Like the etiology of amblyopia, the source for “amblyaudio” (from the Greek, amblyos – blunt; audio – hearing), may also stem from maladaptive plasticity in the central auditory system during developmental critical periods. In fact, CHL has been associated with a host of changes in subcortical auditory nuclei including alterations in metabolic activity (Tucci et al, 1999), protein synthesis (Hutson et al, 2007), stimulus-evoked spike rates (Mogdans and Knudsen, 1993; Silverman and Clopton, 1977; Sumner et al, 2005), and even cell morphology (Gray et al, 1982; Smith et al, 1983). A history of CHL has also been linked to alterations in temporal dynamics (Xu et al, 2007) and synaptic plasticity (Xu et al, 2010) in the auditory thalamocortical brain slice preparation.…”

Section: Introductionmentioning

confidence: 99%

Monaural Deprivation Disrupts Development of Binaural Selectivity in Auditory Midbrain and Cortex

Popescu

Polley

2010

Neuron

189

207

View full text Add to dashboard Cite

SUMMARY Degraded sensory experience during critical periods of development can have adverse effects on brain function. In the auditory system, conductive hearing loss associated with childhood ear infections can produce long-lasting deficits in auditory perceptual acuity, much like amblyopia in the visual system. Here we explore the neural mechanisms that may underlie “amblyaudio” by inducing reversible monaural deprivation (MD) in infant, juvenile and adult rats. MD distorted tonotopic maps, weakened the deprived ear’s representation, strengthened the open ear’s representation and disrupted binaural integration of interaural level differences (ILD). Bidirectional plasticity effects were strictly governed by critical periods, were more strongly expressed in primary auditory cortex than inferior colliculus, and directly impacted neural coding accuracy. These findings highlight a remarkable degree of competitive plasticity between aural representations and suggest that the enduring perceptual sequelae of childhood hearing loss might be traced to maladaptive plasticity during critical periods of auditory cortex development.

show abstract

Consequences of unilateral hearing loss: Time dependent regulation of protein synthesis in auditory brainstem nuclei

Cited by 16 publications

References 75 publications

Reversible Conductive Hearing Loss: Restored Activity in the Central Auditory System

Reversible Conductive Hearing Loss: Restored Activity in the Central Auditory System

Monaural conductive hearing loss alters the expression of the GluA3 AMPA and glycine receptor α1 subunits in bushy and fusiform cells of the cochlear nucleus

Monaural Deprivation Disrupts Development of Binaural Selectivity in Auditory Midbrain and Cortex

Contact Info

Product

Resources

About