Conservantes en productos de higiene y cosméticos, medicamentos tópicos y productos de limpieza doméstica en España

Pastor‐Nieto, María‐Antonia; Alcántara-Nicolás, Francisco; Melgar-Molero, Virginia; Pérez‐Mesonero, Raquel; Vergara-Sánchez, Aránzazu; Martín-Fuentes, Adriana; González-Muñoz, P.; Eusebio‐Murillo, E De

doi:10.1016/j.ad.2017.04.003

Cited by 31 publications

(9 citation statements)

References 17 publications

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“…Inadequate use of preservatives could either lead to deterioration of the product or increase the risk of adverse reactions in users. Approximately 6% of the population is sensitized to the ingredients of cosmetics, especially to preservatives and fragrances (Halla et al, 2018; Herman, 2019; Pastor‐Nieto et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Integrated approaches to testing and assessment as a tool for the hazard assessment and risk characterization of cosmetic preservatives

Canavez

Corrêa

Isaac

et al. 2021

J of Applied Toxicology

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The safety assessment of cosmetic products is based on the safety of the ingredients, which requires information on chemical structures, toxicological profiles, and exposure data. Approximately 6% of the population is sensitized to cosmetic ingredients, especially preservatives and fragrances. In this context, the aim of this study was to perform a hazard assessment and risk characterization of benzalkonium chloride (BAC), benzyl alcohol (BA), caprylyl glycol (CG), ethylhexylglycerin (EG), chlorphenesin (CP), dehydroacetic acid (DHA), sodium dehydroacetate (SDH), iodopropynyl butylcarbamate (IPBC), methylchloroisothiazolinone and methylisothiazolinone (MCI/MIT), methylisothiazolinone (MIT), phenoxyethanol (PE), potassium sorbate (PS), and sodium benzoate (SB). Considering the integrated approaches to testing and assessment (IATA) and weight of evidence (WoE) as a decision tree, based on published safety reports. The hazard assessment was composed of a toxicological matrix correlating the toxicity level, defined as low (L), moderate (M), or high (H) and local or systemic exposure, considering the endpoints of skin sensitization, skin irritation, eye irritation, phototoxicity, acute oral toxicity, carcinogenicity, mutagenicity/genotoxicity, and endocrine activity. In a risk assessment approach, most preservatives had a margin of safety (MoS) above 100, except for DHA, SDH, and EG, considering the worst‐case scenario (100% dermal absorption). However, isolated data do not set up a safety assessment. It is necessary to carry out a rational risk characterization considering hazard and exposure assessment to estimate the level of risk of an adverse health outcome, based on the concentration in a product, frequency of use, type of product, route of exposure, body surface location, and target population.

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Section: Introductionmentioning

confidence: 99%

Integrated approaches to testing and assessment as a tool for the hazard assessment and risk characterization of cosmetic preservatives

Canavez

Corrêa

Isaac

et al. 2021

J of Applied Toxicology

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“…Subsequently, the label of every product was examined and chemicals which could possibly affect human health were detected. The selection of substances was based on scientific evidence: for fragrances the list of 26 allergens which have been identified as skin sensitizer by the Scientific Committee on Consumer Safety (SCCS) and whose names should be listed on the label [ 12 ] was considered; for the other substances a literature’s review was conducted [ 13-15 ] and only those reporting possible harmful effects on human heath were selected.…”

Section: Methodsmentioning

confidence: 99%

Skin Safety and Health Prevention: an Overview of Chemicals in Cosmetic Products

Panìco

Serio

Bagordo

et al. 2019

Journal of Preventive Medicine and Hygiene

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“…In this work, the industrial preservative bronopol (2-bromo-2-nitropropane-1,3-diol, M = 199.989 g mol -1 ) has been selected as model organic pollutant to test the ability of new Cobased air-diffusion cathodes to generate H2O2. As an effective antiseptic, bronopol is ubiquitous in cosmetics, creams and lotions [46]. Lately, important concerns have arisen due to its potential to release formaldehyde, a human carcinogen [47].…”

Section: Catalysts For Example Cos2-based Mwcnts Air-diffusion Cathodes Have Been Recentlymentioning

confidence: 99%

Enhanced electrocatalytic production of H2O2 at Co-based air-diffusion cathodes for the photoelectro-Fenton treatment of bronopol

Guelfi

Álvarez

et al. 2019

Applied Catalysis B: Environmental

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Co, S, P)-decorated multiwalled carbon nanotubes (MWCNTs) have been synthesized following a hydrothermal route as electrocatalysts to manufacture large surface area airdiffusion cathodes with carbon cloth as substrate. The enhanced electrocatalytic H2O2 production as compared with Co-free MWCNTs cathodes was demonstrated in a 2.5-L prepilot plant with either a RuO2-based or boron-doped diamond (BDD) anode, accumulating between 2-and 3-fold greater H2O2 contents with the catalyzed cathode. The good stability of this new material was ensured from the low Co leaching, with less than 9% Co released to solutions upon repeated usage. Aqueous solutions of the brominated organic preservative bronopol with 0.050 M Na2SO4 at pH 3.0 were comparatively treated by electro-oxidation (EO-H2O2), electro-Fenton (EF), UVA-assisted photoelectro-Fenton (PEF) and solar PEF (SPEF) at constant current density. SPEF with BDD anode and the catalyzed cathode showed the best performance, with total bronopol removal at 210 min and 94% mineralization after 360 min at 40 mA cm -2 , thanks to the action of • OH, BDD( • OH) and sunlight. Formic acid was identified as main reaction by-product, whereas Br and N atoms were mainly converted to Br − , BrO3 − and NO3 − . Some unidentified organic by-product containing Br and N was formed as well.

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Conservantes en productos de higiene y cosméticos, medicamentos tópicos y productos de limpieza doméstica en España

Cited by 31 publications

References 17 publications

Integrated approaches to testing and assessment as a tool for the hazard assessment and risk characterization of cosmetic preservatives

Integrated approaches to testing and assessment as a tool for the hazard assessment and risk characterization of cosmetic preservatives

Skin Safety and Health Prevention: an Overview of Chemicals in Cosmetic Products

Enhanced electrocatalytic production of H2O2 at Co-based air-diffusion cathodes for the photoelectro-Fenton treatment of bronopol

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