Conservation of Biological Resources: Why Does It Matter?

Castro, Paula M.; Azul, Anabela Marisa; Paiva, Jorge

doi:10.1007/978-3-319-32318-3_2

Cited by 1 publication

(1 citation statement)

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“…However, these extracts have associated side effects such as muscle and joint pains, hair loss, loss of appetite, diarrhea, nausea and vomiting. Immunostimulation has been considered as one of the possible mechanisms contributing to tumor growth prevention; and is related to immunomodulatory activity through Th1, Th2, and Th17 regulatory activation, hemocytoblasts, regulatory T-cells and mesenchymal stromal cells [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Purification, characterization, and antitumor activity of a novel glucan from the fruiting bodies of Coriolus Versicolor

et al. 2017

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Cancer is one of the most common causes of deaths worldwide. Herein, we report an efficient natural anticancer glucan (CVG) extracted from Coriolus Versicolar (CV). CVG was extracted by the hot water extraction method followed by ethanol precipitation and purified using gas exclusion chromatography. Structural analysis revealed that CVG has a linear α-glucan chain composed of only (1→ 6)-α-D-Glcp. The antitumor activity of CVG on Sarcoma-180 cells was investigated in vitro and in vivo. Mice were treated with three doses of CVG (40, 100, 200 mg/kg body weight) for 9 days. Tumor weight, relative spleen, thymus weight, and lymphocyte proliferation were studied. A significant increase (P< 0.01) in relative spleen and thymus weight and a decrease (P< 0.01) in tumor weight at the doses of 100 and 200 mg/kg were observed. The results obtained demonstrate CVG has antitumor activity towards Sarcoma-180 cells by its immunomodulation activity.

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Section: Introductionmentioning

confidence: 99%