2019
DOI: 10.1101/695486
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Conservation of gene architecture and domains amidst sequence divergence in thehsrωlncRNA gene across theDrosophilagenus: Anin silicoanalysis

Abstract: The non-coding 93D or hsrω locus in Drosophila melanogaster is important for development and cell stress response, produces multiple long non-coding RNAs using two known transcription start sites and four transcription termination sites and includes two exons, one omega intron, one short translatable open reading frame ORFω, long stretch of tandem repeats unique to this locus and an overlapping miRNA gene near its 3' end. Early cytogenetic and cloning studies suggested its functional conservation in the genus … Show more

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“…The ability to modulate TDP-43 and FUS toxicity was previously reported for Drosophila ncRNAs such as Hsrω [47][48][49][50]. In particular, Hsrω depletion in a Drosophila model of TDP-43 proteinopathy was shown to partially rescue TDP-43-induced retinal degeneration.…”
Section: Discussionmentioning
confidence: 55%
“…The ability to modulate TDP-43 and FUS toxicity was previously reported for Drosophila ncRNAs such as Hsrω [47][48][49][50]. In particular, Hsrω depletion in a Drosophila model of TDP-43 proteinopathy was shown to partially rescue TDP-43-induced retinal degeneration.…”
Section: Discussionmentioning
confidence: 55%