Conservation of HIV-1 T cell epitopes across time and clades: validation of immunogenic HLA-A2 epitopes selected for the GAIA HIV vaccine

Further progress on defining highly conserved immunogenic epitopes for a global HIV vaccine: HLA-A3-restricted GAIA vaccine epitopes

“…35,36 Thus far, "GAIA vaccine" epitopes have been selected for HLA class II and for the HLA class I super-types HLA-B7, HLA-A11 and HLA-A2. 26,45,62 The present study describes the process of selecting and evaluating epitopes for HLA-A3. Furthermore, epitopes restricted to these supertype HLA that have been identified based on EpiMatrix Z-score and conservation lead to the selection of epitopes that are both immunogenic and highly conserved.…”