2024
DOI: 10.1101/2024.05.20.595003
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Conservation of the cooling agent binding pocket within the TRPM subfamily

Kate Huffer,
Matthew C.S. Denley,
Elisabeth V. Oskoui
et al.

Abstract: Transient Receptor Potential (TRP) channels are a large and diverse family of tetrameric cation selective channels that are activated by many different types of stimuli, including noxious heat or cold, organic ligands such as vanilloids or cooling agents, or intracellular Ca2+. Structures available for all subtypes of TRP channels reveal that the transmembrane domains are closely related despite their unique sensitivity to activating stimuli. Here we use computational and electrophysiological approaches to exp… Show more

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