1991
DOI: 10.1007/bf01025711
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Conservative and variable regions of homologous snake phospholipases A2 sequences: Prediction of the taxonspecific peptides structure

Abstract: Homologous amino acid sequences of phospholipases A2 (PLA2) of snakes belonging to the families Elapidae, Viperidae, and Colubridae were considered in order to study the conservative and variable regions location. The PLA2 sequences were divided into two groups (taxons) according to the phylogenetic tree reconstructed from the pair similarity matrix. Results of the intergroup comparison were plotted to facilitate the identification of significant conservative and variable regions. It was shown that the results… Show more

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Cited by 5 publications
(4 citation statements)
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References 19 publications
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“…5 and 6), one containing the marine (Aipysurus, Astrotia, Enhydrina, Hydrophis, and Laticauda) and terrestrial Australian (Acanthophis, Notechis, Oxyuranus, Pseudechis, and Pseudonaja) species, and the other containing the African and Asian species (Aspidelaps, Boulengerina, Bungarus, Hemachatus, Maticora, and Naja). This result is similar to the results of earlier phylogenetic studies of PLA 2 s (Dufton and Hider, 1983;Tamiya, 1985;Davidson and Dennis, 1990;Kostetsky et al, 1991) and corresponds largely to McDowell's (1970) cept Laticauda] elapids) and palatine erectors (all terrestrial African, Asian, and American elapids, Laticauda, and Parapistocalamus), respectively. A major difference between our study and McDowell's is our association of Laticauda with the terrestrial Australian and marine elapids.…”
Section: Figsupporting
confidence: 81%
See 1 more Smart Citation
“…5 and 6), one containing the marine (Aipysurus, Astrotia, Enhydrina, Hydrophis, and Laticauda) and terrestrial Australian (Acanthophis, Notechis, Oxyuranus, Pseudechis, and Pseudonaja) species, and the other containing the African and Asian species (Aspidelaps, Boulengerina, Bungarus, Hemachatus, Maticora, and Naja). This result is similar to the results of earlier phylogenetic studies of PLA 2 s (Dufton and Hider, 1983;Tamiya, 1985;Davidson and Dennis, 1990;Kostetsky et al, 1991) and corresponds largely to McDowell's (1970) cept Laticauda] elapids) and palatine erectors (all terrestrial African, Asian, and American elapids, Laticauda, and Parapistocalamus), respectively. A major difference between our study and McDowell's is our association of Laticauda with the terrestrial Australian and marine elapids.…”
Section: Figsupporting
confidence: 81%
“…Several studies have previously considered elapid PLA 2 s (e.g., Dufton and Hider, 1983;Tamiya, 1985;Davidson and Dennis, 1990;Kostetsky et al, 1991) and NXSs (e.g., Tamiya, 1985) in a phylogenetic context, but these studies examined only a subset of the taxa now available.…”
Section: Elapid Venom Proteinsmentioning
confidence: 99%
“…Evolutionary studies of snake venom PLA 2 sequences have been carried out by Dufton and Hider (1983) and Kostetsky et al (1991). The dendrograms they obtained suggest very distinct groupings for group I and group II venom PLAz's.…”
Section: Evolutionary Relationships Of Group II Pla E Sequences Implymentioning
confidence: 99%
“…Structurally, elapid PLA2s are classified into three subclasses: one includes enzymes from Bungarinae, the second contains PLA2s from Hydrophiinae and Laticaudinae and the third includes only fl-bungarotoxin [3,21]. Nigroxins A and B are structurally most similar to PLA2s from the first subclass.…”
Section: Discussionmentioning
confidence: 99%