Purpose: To investigate the effect of preoperative administration of finasteride on intraoperative bleeding during transurethral laser resection of the prostate.
Materials and methods: We retrospectively analyzed 181 patients who underwent transurethral laser resection of the prostate between Jan 2021 and Dec 2023. Patients were divided into two groups based on whether finasteride were used (n = 99) or not (n = 82). The following parameters were collected: age, height, weight and body mass index (BMI), international prostate symptom score (IPSS), quality of life (QoL) score, prostate‐specific antigen (PSA), prostate volume, operation time, hospital stay, catheterization duration, re‐catheterization , preoperative and postoperative hemoglobin concentrations, preoperative and postoperative serum sodium concentrations, postoperative urinary tract infection (UTI) rate, hospitalization costs. We compared the two groups using Student’s t test, Mann–Whitney U test and χ2 test for quantitative and categorical variables, respectively. Linear regression model was used to identify predictive factors of transurethral laser resection of the prostate.
Results: Compared with the non-finasteride group, the finasteride group had a lower bleeding level (Δhemoglobin 3.63±8.73 g/L vs. 8.10±11.14 g/L, p=0.026), and a lower hospitalization costs (22796.89±5482.40 Yuan vs. 25113.27±4510.60 Yuan, p=0.008). In multivariate analyses, the regular use of finasteride (r=-0.237, p=0.002) and level of PSA (r=0.233, p=0.006) was the indepentent predictive factor of intraoperative bleeding during transurethral laser resection of the prostate.
Conclusion: The regular use of finasteride before transurethral laser resection of the prostate help to reduce intraoperative bleeding level.