Conservative Management of Lumbar Disc Herniation With Associated Radiculopathy

Hahne, Andrew J.; Ford, Jon; McMeeken, Joan

doi:10.1097/brs.0b013e3181cc3f56

Cited by 174 publications

(117 citation statements)

References 81 publications

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“…Our study will explore the frequency of usage of these technique systems in particular musculoskeletal conditions. With regards to the specific conditions we surveyed there is only limited positive evidence available in the literature for manipulative treatment (in isolation or as part of the therapy) of cervicogenic headache [15], myofascial pain syndrome [10], cervical radiculopathy [16], lumbar disc syndrome [2], lumbar stenosis [17], lumbar disc herniation [18,19] and sacroiliac dysfunction [20]. However, the evidence is weak due to lack of randomised controlled trials.…”

Section: Introductionmentioning

confidence: 99%

Chiropractic treatment approaches for spinal musculoskeletal conditions: a cross-sectional survey

2014

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Background: There are several chiropractic spinal manipulative technique systems. However, there is limited research differentiating the efficacy of these techniques. Additionally, chiropractors may also use ancillary procedures in the treatment of musculoskeletal pain, a variable that also needs to be considered when measuring the efficacy of chiropractic therapy. No data is currently available regarding the frequency of usage of chiropractic technique systems or ancillary procedures for the treatment of specific musculoskeletal conditions. Knowing which technique systems and ancillary procedures are used most frequently may help to direct future research. The aim of this research was to provide insight into which treatment approaches are used most frequently by Australian chiropractors to treat spinal musculoskeletal conditions. Methods: Cross-sectional survey design. The survey was sent online to the members of the two main Australian chiropractic associations between 30 th June 2013 and 7 th August 2013. The participants were asked to provide information on treatment choices for specific spinal musculoskeletal conditions. Results: 280 respondents. Diversified manipulative technique was the first choice of treatment for most of the included conditions. Diversified was used significantly less in 4 conditions; cervical disc syndrome with radiculopathy and cervical central stenosis were more likely to be treated with Activator; flexion distraction technique was used almost as much as Diversified in the treatment of lumbar disc syndrome with radiculopathy and lumbar central stenosis. More experienced Australian chiropractors use more Activator and soft tissue therapy and less Diversified technique compared to their less experienced peers. The majority of responding chiropractors used ancillary procedures such as soft tissue techniques and exercise prescription in the treatment of spinal musculoskeletal conditions.

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Section: Introductionmentioning

confidence: 99%

Chiropractic treatment approaches for spinal musculoskeletal conditions: a cross-sectional survey

2014

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“…Approximately 90% of the cases radiculopathy are caused by a herniation of the lumbar intervertebral disc, making it the most common cause 25,26) . The highest prevalence is seen in the 30-to 50-year-old age group.…”

Section: ⅳ Discussionmentioning

confidence: 99%

A descriptive statistical analysis of inpatients with lumbar disc herniation at a Korean medicine hospital in 2014

et al. 2017

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“…This is particularly interesting as disk cells are of notochordal in origin [15], and do not contain either sensory or motor neurons under physiological conditions [16]. Recently, Cuesta et al [17] showed the presence and localization of different ASICs in the human healthy intervertebral disk, and an increased expression of ASICs in the degenerated intervertebral disk, indicating that ASICs may be involved in intervertebral disk degeneration.…”

Section: Discussionmentioning

confidence: 99%

Expression of acid-sensing ion channels in nucleus pulposus cells of the human intervertebral disk is regulated by non-steroid anti-inflammatory drugs

Sun¹,

Jin²,

Zhang³

et al. 2014

ABBS

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Non-steroid anti-inflammatory drugs (NSAIDs) are generally used in the treatment of inflammation and pain through cyclooxygenase (COX) inhibition. Mounting evidence has indicated additional COX-independent targets for NSAIDs including acid-sensing ion channels (ASICs) 1a and 3. However, detailed function and mechanism of ASICs still remain largely elusive. In this study, the impact of NSAIDs on ASICs in nucleus pulposus cells of the human intervertebral disk was investigated. Nucleus pulposus cells were isolated and cultured from protruded disk tissues of 40 patients. It was shown that ASIC1a and ASIC3 were expressed and functional in these cells by analyzing protongated currents after ASIC inhibition. We further investigated the neuroprotective capacity of ibuprofen (a COX inhibitor), psalmotoxin-1 (PcTX1, a tarantula toxin specific for homomeric ASIC1a), and amiloride (a classic inhibitor of the epithelial sodium channel ENaC/DEG family to which ASICs belong). PcTX1-containing venom has been shown to be comparable with amiloride in its neuroprotective features in rodent models of ischemia. Taken together, our data showed that amiloride, PcTX1, and ibuprofen decreased ASIC protein expression and thereby exerted protective effects from ASIC inhibition-mediated cell damage.

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Conservative Management of Lumbar Disc Herniation With Associated Radiculopathy

Cited by 174 publications

References 81 publications

Chiropractic treatment approaches for spinal musculoskeletal conditions: a cross-sectional survey

Chiropractic treatment approaches for spinal musculoskeletal conditions: a cross-sectional survey

A descriptive statistical analysis of inpatients with lumbar disc herniation at a Korean medicine hospital in 2014

Expression of acid-sensing ion channels in nucleus pulposus cells of the human intervertebral disk is regulated by non-steroid anti-inflammatory drugs

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