Conservative management of multi-trauma induced peritonitis: Experience, outcomes, and indications

Abstract

Insulin, a small protein with 51 amino acids synthesized by pancreatic β-cells, is crucial to sustain glucose homeostasis at biochemical and molecular levels. Numerous metabolic dysfunctions are related to insulin-mediated altered glucose homeostasis. One of the significant pathophysiological conditions linked to the insulin associated disorder is diabetes mellitus (DM) (type 1, type 2, and gestational). Insulin resistance (IR) is one of the major underlying causes of metabolic disorders despite its association with several physiological conditions. Metabolic syndrome (MS) is another pathophysiological condition that is associated with IR, hypertension, and obesity. Further, several other pathophysiological disorders/diseases are associated with the insulin malfunctioning, which include polycystic ovary syndrome, neuronal disorders, and cancer. Insulinomas are an uncommon type of pancreatic β-cell-derived neuroendocrine tumor that makes up 2% of all pancreatic neoplasms. Literature revealed that different biochemical events, molecular signaling pathways, microRNAs, and microbiota act as connecting links between insulin disorder and associated pathophysiology such as DM, insuloma, neurological disorder, MS, and cancer. In this review, we focus on the insulin-related disorders and the underlying mechanisms associated with the pathophysiology.

Differentiated Approach to Antihypoxic, Endoportal and Phage Therapy for Advanced Purulent Peritonitis

“…Secondary peritonitis and intra-abdominal sepsis are a global issue in public healthcare. The life-threatening systemic damage resulting from intra-abdominal sepsis has long been known, but remains insufficiently studied [1][2][3][4][5]. Direct surgical treatment for diffuse peritonitis is well developed and understood, however, there are not enough systemic treatment methods to control the subsequent systemic inflammatory reaction [6][7][8].…”

Perioperative Management on Septic Condition et Causa General Peritonitis: Case Report

“…Appendicitis and perforation of the ileum or cecum are the most common causes of peritonitis with an estimated prevalence of around 43.1% and 35.1% respectively (Purwanto & Astrawinata, 2018). Some other causes of peritonitis include gastroduodenal perforation, ruptured abscess, perforated peptic ulcer, and trauma (Chen et al, 2023;Ross et al, 2018). The aim of this case report is to present and discuss perioperative anesthetic management, morbidity and mortality in patients with sepsis and septic shock due to generalized peritonitis.…”

Fusobacterium nucleatum: An Overview of Evidence, Demi-Decadal Trends, and Its Role in Adverse Pregnancy Outcomes and Various Gynecological Diseases, including Cancers

“…Peritonitis is a medical condition characterized by inflammation of the peritoneum, which is the membrane that lines the abdominal cavity [116]. This inflammation can be caused by various factors, such as underlying health conditions or the presence of infectious agents.…”