1998
DOI: 10.1074/jbc.273.21.12870
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Conservative Mutations in the Immunosuppressive Region of the Bovine Leukemia Virus Transmembrane Protein Affect Fusion but Not Infectivity in Vivo

Abstract: Many retroviruses, including bovine leukemia virus (BLV), contain a highly conserved region located about 40 amino acids downstream from the fusion peptide within the sequence of the external domain of the transmembrane (TM) protein. This region is notably thought to be involved in the presentation of the NH 2 -terminal peptide to allow cell fusion. By using hydrophobic cluster analysis and by analogy with the influenza A hemagglutinin structures, the core of the TM structure including this particular region w… Show more

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Cited by 23 publications
(27 citation statements)
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“…Previous studies show that antibodies directed against the coiled-coil region of other retroviruses such as human immunodeficiency virus and bovine leukemia virus can lead to virus neutralization (62,63).…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies show that antibodies directed against the coiled-coil region of other retroviruses such as human immunodeficiency virus and bovine leukemia virus can lead to virus neutralization (62,63).…”
Section: Discussionmentioning
confidence: 99%
“…110 Furthermore, these mutant proviruses brought to light their potential suitability as attenuated virus vaccines. The candidates studied included hybrid, simpler retrovirus derivatives from a wild type, lacking the regulatory genes and cis acting response sequences; 107,[111][112][113] noninfectious provirus deficient for cell fusion, but with wild-type-like propagation levels; 114 and infectious provirus with impaired propagation ability. 21,107,108,110,[115][116][117] The perfect vaccine that induces neutralizing antibodies and protective cell-mediated immune responses remains elusive.…”
Section: -101mentioning
confidence: 99%
“…In fact, we have previously used the reverse genetics approach in order to assess the role of viral proteins in the leukemogenesis process. We identified three categories of mutations: (i) those that completely abolish infectivity (10,31,33,35), (ii) those that are apparently silent and do not affect replication (10,19,26,33), and (iii) intermediates that do not completely abolish infectivity but reduce proviral loads (10,15,19,31,34). Sheep 245 and 277 described here were infected with recombinant viruses belonging to the third category (15).…”
mentioning
confidence: 99%