Conservative Therapy in Two Cases of Non-Hodgkin Lymphoma of the Penis: Case Reports With Review of the Literature

Delicato, Giampaolo; Baffigo, Giulio; Bianchi, Daniele; Farullo, Giuseppe; Signore, Stefano; Tartaglia, Edoardo; Corvese, Francesco; Ferdinandi, Vincenzo

doi:10.4021/wjon438w

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…The E-CHOP regimen alone, or combined with rituximab, which is a chimeric monoclonal antibody against the CD20 B-cell antigen, has become the current recommended treatment for DLBCL. In the majority of reported cases, following chemotherapy treatment, complete resolution of the disease was observed for between four months and six years ( 10 , 15 , 19 – 26 ). However mortalities due to this malignancy have also been reported ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of rare lymphoma is difficult and may be delayed without specific symptoms and thus, treatment of this lesion remains controversial. Chemotherapy is the main treatment adminstered, however, immunotherapy, radiotherapy and penile preservation have all been reported ( 3 , 4 ) and a combined treatment modality is usually recommended ( 5 ). The current study reports a patient diagnosed with primary malignant penile lymphoma, with metastasis in the lungs and brain, and poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Priapism as the initial symptom of primary penile lymphoma: A case report

et al. 2014

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Primary penile lymphoma presenting with priapism as the initial symptom is extremely rare. In total, <10 cases have been previously reported. The diagnosis can be difficult and patients often develop metastasis. The current study reports the case of a 48-year-old male, who presented with a one-month history of painless priapism. On admission to Yantai Yuhuangding Hospital Affiliated to Qingdao University (Yantai, China), examination revealed an erect penis, enlarged lymph nodes in the bilateral inguinal and swelling in the thighs. A biopsy was taken from the right inguinal lymph node and the pathological diagnosis confirmed a diffuse large B-cell type of non-Hodgkin’s lymphoma, while an enhanced computed tomography scan of the chest revealed evidence of the invasion of malignant lymphoma cells. Priapism disappeared two days following the completion of the first cycle of chemotherapy with the E-CHOP regimen (cyclophosphamide, vincristine, prednisone, epirubicin and etoposide); however, evidence of brain metastases was observed one month later, which was confirmed by magnetic resonance imaging. The patient received cranial radiotheraphy and systemic treatment for cerebral edema. The patient did not respond well to treatment and succumbed to the disease three months following the initial diagnosis of lymphoma. Lymphoma may be difficult to diagnose, depending on the initial symptoms; therefore, the patient history must be carefully assessed so as to determine an early diagnosis and prevent metastasis, thus improving the prognostic outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Priapism as the initial symptom of primary penile lymphoma: A case report

et al. 2014

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“…In addition to radical surgery, many cases showed that penile preservation strategies were also effective treatments for the patients. Delicato et al 6 suggested that conservative therapy could be considered as the first-choice approach with a curative goal because of the aesthetic problems and erectile dysfunction caused by surgery. Combined-modality treatments were used in some cases.…”

Section: Dear Editormentioning

confidence: 99%