Conservative therapy of frequency, urgency and urge incontinence: A double-blind clinical trial of flavoxate hydrochloride, exybutinin chloride, emepronium bromide and placebo

Comparison of Urodynamic Findings and Response to Oxybutynin in Nocturnal Enuresis

“…Owing to antispasmodic and anticholinergic properties, in addition to analgesic and local anesthetic effects, objective improvement of urody namic parameters has been demonstrated in neurogenic bladders [1-3, 17]. In accordance, subjective improve ment is unanimously reported in urge incontinence, al though significant changes in objective urodynamic vari ables remain controversial [14,[18][19][20]. Objective param eters specifying the quality of treatment response in en uresis are still lacking.…”

Effect of Trospium Chloride on Urodynamic Parameters in Patients with Detrusor Hyperreflexia due to Spinal Cord Injuries

“…For instance, the efficacy of flavoxate and emepronium bromide has been doubted because objective param eters show no difference from placebo [14,15]. Propan theline, methantheline and oxybutynin seem to be supe rior in efficacy when compared to placebo [8], but the incidence and severity of side-effects are reported to be rather high.…”

772 Adverse Event Assessment of Antimuscarinics for Treating Overactive Bladder: A Network Meta-Analytic Approach

“…Three articles [19][20][21] not specifying adverse events, one article [22] not differentiating adverse events between antimuscarinic and placebo, six articles [23][24][25][26][27][28] not discriminating adverse events between different fixed dosages, and three articles [29][30][31] only comparing different releases within the same antimuscarinic and dosage were excluded. Thus, we finally included 69 trials including one report [66] with two different age strata ( Table 2, Data S2).…”