“…The traditional mainstay for conservative therapeutic management includes orthotic support (Hermann et al, 2014), pharmacological approach (Joshi, 2005;Salini, De Amicis, Abate, Natale, & Di Iorio, 2009), patient education (Stamm et al, 2002), therapeutic exercise (Valdes & von der Heyde, 2012), joint (Villafañe, Silva, & Fernandez-Carnero, 2012) and neural (Villafañe, Silva, & Fernandez-Carnero, 2011) mobilization, or radiotherapy (Kaltenborn, Bulling, Nitsche, Carl, & Hermann, 2016) among others, both isolated or in combination (Deveza et al, 2017). Although a number of them have shown to be effective, most of existing trials on TCMC-OA have demonstrated poor consistent case definition, sparse standardized outcome measures, and inadequate powering, thereby limiting their generalizability to clinical scenarios (Spaans et al, 2015).…”