Conservative treatments for feline fibroadenomatous changes of the mammary gland

Marino, Gabriele; Pugliese, Michela; Pecchia, Fabiana; Garufi, Giuseppe; Lupo, Vincenzo; Giorgio, Stefania Di; Sfacteria, Alessandra

doi:10.5455/ovj.2021.v11.i4.19

Cited by 6 publications

(11 citation statements)

References 12 publications

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“…The relationship between tissue perfusion and wound healing has been well described in dogs and cats [ 5 , 6 , 7 , 8 , 9 , 10 ]. According to other studies, cutaneous microcirculation favors granulation tissue production and cutaneous healing by delivering nutrients and oxygen to the wound site [ 6 , 39 ]. Furthermore, in our study, tissue perfusion increased significantly on days 7 and 14 and then declined by day 25.…”

Section: Discussionmentioning

confidence: 99%

“…The Neem oil used in the production of Hypermix ® is extracted from cold-pressed seeds of the Melia Azadirachta Indica plant and subsequently filtered to remove impurities. Hypericum has been also reported to aid in the healing of ulcerated mammary fibro adenomatous changes in a small number of cats [ 39 ]. However, no reports evaluating the effect of Hypericum on feline cutaneous wound healing have been published so far.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Effectiveness of Medical-Grade Honey and Hypericum Perforatum Ointment on Second-Intention Healing of Full-Thickness Skin Wounds in Cats

Chatzimisios,

Tsioli,

Brellou

et al. 2023

Animals

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This study aimed to determine the effects of two topical treatments on second-intention wound healing in cats. Eight 2 × 2 cm full-thickness wounds were created, four on each side of the dorsal midline of eight laboratory cats, to receive either medical-grade honey ointment (MGH) and its control (HC), or Hypericum-based ointment (HP) and its control (HPC). MGH or HP ointment was applied to four wounds on the same side, while the remaining four were used as controls, chosen at random. Planimetry, laser Doppler flowmetry, daily physical examinations, and histologic examinations on days 0, 7, 14, and 25 were used to assess the healing of wounds. Tissue perfusion was better in the MGH-treated (2.14 ± 0.18 mm/s) and HP-treated wounds (2.02 ± 0.13 mm/s) than in the untreated controls HC (1.59 ± 0.11 mm/s) and HPC (1.60 ± 0.05 mm/s), respectively (p = 0.001). Histopathology revealed that the median edema score was lower in the MGH-treated (2; range 1–4) compared to the HC-treated wounds (3; range 2–4) on day 7 (p < 0.05). The median angiogenesis score was higher on day 7 in the MGH-treated (2; range 1–3) compared to the HP-treated wounds (2; range 1–2) (p = 0.046). The fibroblast concentration was increased in the MGH-treated wounds (3.5; range 3–4) compared to the HP-treated wounds (3; range 2–4) on day 25 (p = 0.046). MGH and HP increased tissue perfusion compared to the untreated controls. The MGH-treated wounds had histologic parameters superior to the HP-treated wounds regarding angiogenesis and fibroblast concentration in cutaneous wound healing in cats. Topical application of MGH and HP did not accelerate the healing process of feline cutaneous wounds.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effectiveness of Medical-Grade Honey and Hypericum Perforatum Ointment on Second-Intention Healing of Full-Thickness Skin Wounds in Cats

Chatzimisios,

Tsioli,

Brellou

et al. 2023

Animals

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“…The dosage of aglepristone used in this report was therefore increased to 15 mg/kg, according to the indications provided in the cited literature, but differently from that presented in previous reports [ 7 ] for the treatment of feline pyometra. This more appropriate dose, based on pharmacokinetic considerations [ 20 , 22 ], has recently also been described by Marino et al in the treatment of feline mammary fibroadenomatosis [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of a Modified Administration Protocol for the Medical Treatment of Feline Pyometra

Attard

Bucci

Parrillo

et al. 2022

Veterinary Sciences

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Pyometra is a common uterine disease of dogs and cats, typical of the luteal phase. Traditionally, ovariohysterectomy was considered the elective treatment for pyometra, but in some cases, such as breeding subjects or patients with a high anesthesiologic risk, medical treatment is preferred. Aglepristone is a progesterone receptor blocker and its use proved to be effective for the medical treatment of pyometra in bitches and queens. The aim of this work is to report the effectiveness, in the feline species, of a modified aglepristone administration protocol. Five intact queens were referred to veterinary care centers for pyometra. Aglepristone (15 mg/kg) was administered at D0, D2, D5, and D8, as described by Contri and collaborators for dogs. An antibiotic treatment (marbofloxacin, 3 mg/kg) was associated, and uterine conditions were checked with regular ultrasonographic exams. The uterus returned to its normal condition 10 days after starting the treatment and no adverse effects were reported. After treatment, three queens had an uneventful pregnancy. Even if the treated group was restricted and homogeneous, the proposed modified protocol proved to be useful and promising for the medical treatment of pyometra in cats; further studies are planned to verify its effectiveness in the long-term prevention of recurrence.

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“…Mastitis may occur secondary to FMFH in queens (Vaisu et al, 2023). Although the exact pathogenesis of fibroepithelial hyperplasia in cats remains unclear, it is proposed that the interaction of progesterone or synthetic progestins with progesterone receptors on stromal and epithelial cells stimulates local growth hormone expression, leading to the development and growth of mammary gland (Kucukbekir et al, 2020;Marino et al, 2021;Voorwald et al, 2021). In cases where multiple lesions develop, asymmetrical lesions are more frequently found in non-pregnant females, while females being pregnant tend to develop more homogeneous swellings of the mammary glands (Payen-Carreira, 2013).…”

Section: Case History and Observa-tionsmentioning

confidence: 99%

“…In cases where multiple lesions develop, asymmetrical lesions are more frequently found in non-pregnant females, while females being pregnant tend to develop more homogeneous swellings of the mammary glands (Payen-Carreira, 2013). The mammary glands were bilaterally enlarged, and no milk secretion was detected (Marino et al, 2021). Systemic effects of the disease include anaemia, pale mucous membranes, high fever, tachycardia, lethargy and anorexia (Ucmak et al, 2011;Kucukbekir et al, 2020) (Marino et al, 2021).…”

Section: Case History and Observa-tionsmentioning

confidence: 99%

Feline Mammary Fibroepithelial Hyperplasia in a Pregnant Persian Cat: A Case Report

K.,

et al. 2023

JIVA

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A one-year-old pregnant Persian cat was presented to the outpatient medicine unit of university veterinary hospital, Kokkala, Thrissur, Kerala, with the complaint of sudden onset swelling of the mammary glands. Physical examination of mammary glands showed severely affected right and left inguinal mammary gland. On mammary ultrasonography, enlarged inguinal mammary lobes were visualized as a well-circumscribed solid mass of granular, slightly hyperechoic texture, with regularly delimited margins. Based on the history, clinical signs and ultrasonographic imaging the case was diagnosed as feline mammary fibroepithelial hyperplasia (FMFH), mammary ultrasonography.The animal was conservatively treated with amoxicillin-clavulanate (@12.5 mg/kg orally 12-hour interval); topical daily massage of Aloe vera emollient gel.Animal showed an uneventful recovery and kittened three live kittens.

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Conservative treatments for feline fibroadenomatous changes of the mammary gland

Cited by 6 publications

References 12 publications

Evaluation of the Effectiveness of Medical-Grade Honey and Hypericum Perforatum Ointment on Second-Intention Healing of Full-Thickness Skin Wounds in Cats

Evaluation of the Effectiveness of Medical-Grade Honey and Hypericum Perforatum Ointment on Second-Intention Healing of Full-Thickness Skin Wounds in Cats

Effectiveness of a Modified Administration Protocol for the Medical Treatment of Feline Pyometra

Feline Mammary Fibroepithelial Hyperplasia in a Pregnant Persian Cat: A Case Report

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