Conservative Versus Liberal Red Cell Transfusion in Acute Myocardial Infarction (the CRIT Randomized Pilot Study)

Cooper, Howard A.; Rao, Sunil V.; Greenberg, Michael D.; Rumsey, Maria P.; McKenzie, Marcus E.; Alcorn, Kirsten; Panza, Julio A.

doi:10.1016/j.amjcard.2011.06.014

Cited by 220 publications

(157 citation statements)

References 9 publications

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“…W większości badań służących ocenie różnych protokołów przetoczeń liberalną strategię przetoczeń krwi zdefiniowano jako każde przetoczenie krwinek czerwonych przy stężeniu hemoglobiny < 9,0 g/dl. Restrykcyjną strategię przetoczeń zdefiniowano jako każdą transfuzję przy wartości hemoglobiny < 7,0 g/dl [296][297][298][299]. W metaanalizie 10 badań obejmujących 203 665 pacjentów (9 badań obserwacyjnych i 1 RCT z udziałem 45 pacjentów) z ACS (zarówno STEMI, jak i NSTEMI-ACS) zaobserwowano, że przetoczenie krwi lub liberalna strategia przetoczeń wiązały się ze zwiększoną śmiertelnością ogólną [18,2% vs. 10,2%; RR 2,91 (95% CI 2,46-3,44); p < 0,001] w porównaniu z chorymi niepoddanymi transfuzji lub u których zastosowano restrykcyjną strategię przetoczeń [298].…”

Section: Przetoczenie Preparatów Krwiunclassified

2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Roffi¹,

Patrono²,

Collet³

et al. 2015

Kardiol Pol

210

165

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Section: Przetoczenie Preparatów Krwiunclassified

2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Roffi¹,

Patrono²,

Collet³

et al. 2015

Kardiol Pol

210

165

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“…Two recent systematic reviews in cardiac surgery [19] and in perioperative transfusion practice (including cardiac surgery) [20] reported higher mortality with a restrictive transfusion threshold. Our systematic review [21] found only 11 blood transfusion threshold randomized controlled trials (RCTs) that included patients with co-existing CVD, either as the whole population [10,[22][23][24], as a pre-defined subgroup [9,11,25] or as a high proportion of patients [14,[26][27][28]. We found no evidence of a difference in 30-day mortality between restrictive and liberal transfusion thresholds.…”

Section: Evidence In Patients With Co-existing Cardiovascular Diseasementioning

confidence: 80%

Anemia and Blood Transfusion in the Critically Ill Patient with Cardiovascular Disease

Docherty¹,

Walsh²

2017

Annual Update in Intensive Care and Emergency Medicine

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“…In 2011 Cooper et al randomised 45 patients with acute myocardial infarction (AMI) to either a restrictive (Hct <30%) or liberal transfusion protocol (Hct <24%). 6 Restrictive arm patients had a lower incidence of in-hospital death, recurrent myocardial infarction and congestive heart failure (38% vs 13%, p=0.046). This study was not sufficiently powered to detect differences in clinical outcomes.…”

Section: Indications For Prbc Transfusions In Patients With Cadmentioning

confidence: 93%

An evidence-based approach to red blood cell transfusions in asymptomatically anaemic patients

Chan

2015

annals

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INTRODUCTION Surgeons and physicians encounter blood transfusions on a daily basis but a robust evidence-based strategy on indications and timing of transfusion in asymptomatic anaemic patients is yet to be determined. For judicious use of blood products, the risks inherent to packed red blood cells, the patient's co-morbidities and haemoglobin (Hb)/haematocrit levels should be considered. This review critiques and summarises the latest available evidence on the indications for transfusions in healthy and cardiac disease patients as well as the timing of transfusions relative to surgery. METHODS An electronic literature search of the MEDLINE ® , Google Scholar™ and Trip databases was conducted for articles published in English between January 2006 and January 2015. Studies discussing timing and indications of transfusion in medical and surgical patients were retrieved. Bibliographies of studies were checked for other pertinent articles that were missed by the initial search. FINDINGS Six level 1 studies (randomised controlled trials or systematic reviews) and six professional society guidelines were included in this review. In healthy patients without cardiac disease, a restrictive transfusion trigger of Hb 70-80g/l is safe and appropriate whereas in cardiac patients, the trigger is Hb 80-100g/l. The literature on timing of transfusions relative to surgery is limited. For the studies available, preoperative transfusions were associated with a decreased incidence of subsequent transfusions and timing of transfusions did not affect the rates of colorectal cancer recurrence.

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Conservative Versus Liberal Red Cell Transfusion in Acute Myocardial Infarction (the CRIT Randomized Pilot Study)

Cited by 220 publications

References 9 publications

2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Anemia and Blood Transfusion in the Critically Ill Patient with Cardiovascular Disease

An evidence-based approach to red blood cell transfusions in asymptomatically anaemic patients

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