1988
DOI: 10.1016/0896-6273(88)90210-3
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Conserved and variable regions in the subunits of brain type II Ca2+/calmodulin-dependent protein kinase

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Cited by 136 publications
(85 citation statements)
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“…Initially, this conclusion was based on the observations that, following separation of the subunits by SDS/polyacrylamide-gel electrophoresis and renaturation, both the a and fl subunits of the rat brain kinase bind 125-labelled calmodulin [7,11,12,14] and undergo autophosphorylation [43]. This conclusion has been confirmed by the recent publication of amino acid sequences for the a [31,32], , [44] and /1' [33] subunits of the rat brain kinase deduced from cDNA clones. All the rat brain kinase subunits contain the consensus sequences for ATP binding, protein kinase catalytic activity and calmodulinbinding domains, as depicted schematically in Fig.…”
Section: Species Tissue and Subcellular Distributionmentioning
confidence: 52%
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“…Initially, this conclusion was based on the observations that, following separation of the subunits by SDS/polyacrylamide-gel electrophoresis and renaturation, both the a and fl subunits of the rat brain kinase bind 125-labelled calmodulin [7,11,12,14] and undergo autophosphorylation [43]. This conclusion has been confirmed by the recent publication of amino acid sequences for the a [31,32], , [44] and /1' [33] subunits of the rat brain kinase deduced from cDNA clones. All the rat brain kinase subunits contain the consensus sequences for ATP binding, protein kinase catalytic activity and calmodulinbinding domains, as depicted schematically in Fig.…”
Section: Species Tissue and Subcellular Distributionmentioning
confidence: 52%
“…species for each subunit [33]. Within the neuron, CaMkinase II appears to be distributed in the spines, somata, axons, dendrites and nerve terminal, with little in the nuclei [38].…”
Section: Species Tissue and Subcellular Distributionmentioning
confidence: 99%
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“…This molecule, termed human CaMK IIb 1 differed from the rat subtype b by the absence of the sequence in the first and the third variable domain termed V1 and V3 (Fig. 1B,C) [44]. Furthermore we found a second coding sequence of 1437 bp, which had the same nucleotide sequence as the subtype b 1 but had a 72 bp deletion at position 988 (EMBL AJ252 237).…”
Section: Resultsmentioning
confidence: 78%
“…The differences between rat and human concerned the presence or absence of the variable domains. The V 1 -region [43,44] was absent in all three human b-subtypes identified. The variations between the 3 b-subtypes described here all occurred in the V 2 -region and V 3 -region.…”
Section: Discussionmentioning
confidence: 97%