Conserved aspartate‐to‐glycine mutation in tyrosinase is associated with albino phenotype in domestic guinea pigs (<i>Cavia porcellus</i>)

Yu, Feng; Jiao, Shuyu; Lai, Weining; Liu, Zhengxi; Zhu, Mingyuan; Zhu, Wen; Bai, Chen; Zhang, Yonghong; Zhang, Jiabao; Yan, Shouqing

doi:10.1111/age.12683

“…Chicken [39][40][41] Ungulates Water buffalo [42], Cattle [43], Red deer [44], Asinara donkey [45] Rodents House mouse [46], Wistar rat [47], Domestic guinea pig [48] Primates Crab-eating macaque [49], Capuchin monkey [50], Hamadryas baboon [51], Human [reviewed in 52]…”

Section: Fishmentioning

confidence: 99%

A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius)

Brown

¹

,

K²,

D³

et al. 2022

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Color morphs in ball pythons (Python regius) provide a unique and largely untapped resource for understanding the genetics of coloration in reptiles. Here we use a community-science approach to investigate the genetics of three color morphs affecting production of the pigment melanin. These morphs—Albino, Lavender Albino, and Ultramel—show a loss of melanin in the skin and eyes, ranging from severe (Albino) to moderate (Lavender Albino) to mild (Ultramel). To identify genetic variants causing each morph, we recruited shed skins of pet ball pythons via social media, extracted DNA from the skins, and searched for putative loss-of-function variants in homologs of genes controlling melanin production in other vertebrates. We report that the Albino morph is associated with missense and non-coding variants in the gene TYR. The Lavender Albino morph is associated with a deletion in the gene OCA2. The Ultramel morph is associated with a missense variant and a putative deletion in the gene TYRP1. Our study is one of the first to identify genetic variants associated with color morphs in ball pythons and shows that pet samples recruited from the community can provide a resource for genetic studies in this species.

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“…House mouse (Yokoyama et al, 1990), Wistar rat (Blaszczyk et al, 2005), Domestic guinea pig (Yu et al, 2018) Primates Crab-eating macaque (Kim et al, 2017), Capuchin monkey (Galante Rocha de Vasconcelos et al, 2017), Hamadryas baboon (Koga et al, 2020), Human (reviewed in Montoliu et al, 2014) Other mammals…”

Section: Rodentsmentioning

confidence: 99%

“…Asinara donkey [45] Rodents House mouse [46], Wistar rat [47], Domestic guinea pig [48] Primates Crab-eating macaque [49], Capuchin monkey [50], Hamadryas baboon [51], Human [reviewed in 52] Other mammals Humpback whale [53], Ferret [54], American mink [55], Domestic cat [56][57][58], Silver fox [59]…”

Section: Birdsmentioning

confidence: 99%

A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius)

Ar

¹

,

K

²

,

D

³

et al. 2021

Preprint

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Color morphs in ball pythons (Python regius) provide a unique and largely untapped resource for understanding the genetics of coloration in reptiles. Here we use a community-science approach to investigate the genetics of three color morphs affecting production of the pigment melanin. These morphs—Albino, Lavender Albino, and Ultramel—show a loss of melanin in the skin and eyes, ranging from severe (Albino) to moderate (Lavender Albino) to mild (Ultramel). To identify genetic variants causing each morph, we recruited shed skins of pet ball pythons via social media, extracted DNA from the skins, and searched for putative loss-of-function variants in homologs of genes controlling melanin production in other vertebrates. We report that the Albino morph is associated with missense and non-coding variants in the gene TYR. The Lavender Albino morph is associated with a deletion in the gene OCA2. The Ultramel morph is associated with a missense variant and a putative deletion in the gene TYRP1. Our study is one of the first to identify genetic variants associated with color morphs in ball pythons and shows that pet samples recruited from the community can provide a resource for genetic studies in this species.

show abstract

“…These findings indicate that the albino phenotype in silver foxes is recessive as in other animals. []…”

mentioning

confidence: 99%

A single base insertion in the tyrosinase gene is associated with albino phenotype in silver foxes (Vulpes vulpes)

Yan

¹

,

Zhao

²

,

Hu

³

et al. 2019

Self Cite

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Conserved aspartate‐to‐glycine mutation in tyrosinase is associated with albino phenotype in domestic guinea pigs (Cavia porcellus)

Cited by 4 publications

References 8 publications

A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius)

A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius)

A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius)

A single base insertion in the tyrosinase gene is associated with albino phenotype in silver foxes (Vulpes vulpes)

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