2020
DOI: 10.21203/rs.2.17995/v3
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Conserved associations between G-quadruplex-forming DNA motifs and virulence gene families in malaria parasites

Abstract: Background : The Plasmodium genus of malaria parasites encodes several families of antigen-encoding genes. These genes tend to be hyper-variable, highly recombinogenic and variantly expressed. The best-characterized family is the var genes, exclusively found in the Laveranian subgenus of malaria parasites infecting humans and great apes. Var genes encode major virulence factors involved in immune evasion and the maintenance of chronic infections. In the human parasite P. falciparum , var gene recombination … Show more

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“…For example, among pathogens, Plasmodium falciparum, the protozoan eukaryote causing malaria, contains a number of G4-forming sequences [putative quadruplex sequences (PQSs)]. These motifs are found near var genes, which encode P. falciparum erythrocyte membrane protein 1, a group of variant immunodominant surface antigens esteemed as crucial virulence factors (Gage and Merrick, 2020;Gazanion et al, 2020). Var genes are expressed in a mutually exclusive manner, and P. falciparum periodically switches on or off different genes to express various products.…”
Section: Introductionmentioning
confidence: 99%
“…For example, among pathogens, Plasmodium falciparum, the protozoan eukaryote causing malaria, contains a number of G4-forming sequences [putative quadruplex sequences (PQSs)]. These motifs are found near var genes, which encode P. falciparum erythrocyte membrane protein 1, a group of variant immunodominant surface antigens esteemed as crucial virulence factors (Gage and Merrick, 2020;Gazanion et al, 2020). Var genes are expressed in a mutually exclusive manner, and P. falciparum periodically switches on or off different genes to express various products.…”
Section: Introductionmentioning
confidence: 99%