“…Here, YidC is required for the insertion of the N-terminal region of CyoA into the membrane, followed by the translocation of the more complex C-terminal domain by the Sec translocon (4,9,43). While YidC can act in concert with the Sec translocon, other studies have shown that YidC also can function as an independent insertase for small proteins, such as the M13 and Pf3 phage coat proteins, the subunits a and c of the F 1 F o ATPase (F o a and F o c), and subunit K of the NADH dehydrogenase complex (27,30,31,46). It has been shown that both aerobic and anaerobic respiratory chain complexes are affected in YidC-depleted cells (27,28,46), resulting in a reduction of the proton-motive force (PMF).…”