Conserved Patterns of Trigeminal Somatosensory System Organization in Mammals

Sawyer, Eva K.

doi:10.1159/000460812

Cited by 2 publications

(2 citation statements)

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“…Rodent models also allow us to control for any environmental influences that can contribute to an ASD phenotype. Further, neural mechanisms underlying sensory processing are well-conserved between humans and rodents, and several genetic rodent models relevant to idiopathic and syndromic forms of ASD display abnormal sensitivity to somatosensory stimuli (Table 1) [58].…”

Section: Rodent Models Relevant To Syndromic Asd With a Somatosensorymentioning

confidence: 99%

Mechanisms of Tactile Sensory Phenotypes in Autism: Current Understanding and Future Directions for Research

Schaffler

Middleton

Abdus-Saboor

2019

Curr Psychiatry Rep

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Purpose of Review This review aims to summarize the current body of behavioral, physiological, and molecular knowledge concerning tactile sensitivity in autism spectrum disorder (ASD), with a focus on recent studies utilizing rodent models. Recent Findings Mice with mutations in the ASD-related genes, Shank3, Fmr1, UBE3A, and Mecp2, display tactile abnormalities. Some of these abnormalities appear to be caused by mutation-related changes in the PNS, as opposed to changes in the processing of touch stimuli in the CNS, as previously thought. There is also growing evidence suggesting that peripheral mechanisms may contribute to some of the core symptoms and common comorbidities of ASD. Researchers are therefore beginning to assess the therapeutic potential of targeting the PNS in treating some of the core symptoms of ASD. Summary Sensory abnormalities are common in rodent models of ASD. There is growing evidence that sensory hypersensitivity, especially tactile sensitivity, may contribute to social deficits and other autism-related behaviors.

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Section: Rodent Models Relevant To Syndromic Asd With a Somatosensorymentioning

confidence: 99%

Mechanisms of Tactile Sensory Phenotypes in Autism: Current Understanding and Future Directions for Research

Schaffler

Middleton

Abdus-Saboor

2019

Curr Psychiatry Rep

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“…[ 6 ] The trigeminal somatosensory system has remarkably conserved somatotopic maps across different species of whiskered mammals. [ 7 ] It is postulated that axons carrying sensation from the V1 area are located ventrally and from the V2 and V3 areas are located more dorsally in PPSNT. [ 8 ] Compared to the spinal nucleus of the trigeminal nerve, PPSNT is a considerably smaller nucleus.…”

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confidence: 99%

Dermatomal Dissociated Facial Sensory Loss due to a Partial Trigeminal Pontine Principal Sensory Nucleus Lesion

Maramattom

2024

Annals of Indian Academy of Neurology

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Conserved Patterns of Trigeminal Somatosensory System Organization in Mammals

Cited by 2 publications

References 14 publications

Mechanisms of Tactile Sensory Phenotypes in Autism: Current Understanding and Future Directions for Research

Mechanisms of Tactile Sensory Phenotypes in Autism: Current Understanding and Future Directions for Research

Dermatomal Dissociated Facial Sensory Loss due to a Partial Trigeminal Pontine Principal Sensory Nucleus Lesion

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