Conserved Water Molecule-dependent Docking Strategy and Atom-Based 3D QSAR Studies to Design Heat Shock Protein 90 Inhibitors

Abstract

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Inhibition of PPARγ Gene Particle Downregulates the Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells into Adipocytes

“…At present, RNAi-based gene therapy in experimental research is on genetic diseases. Research findings from both clinical and experimental studies have indicated that ANFH is attributed to pathophysiological changes due to the accumulation of fat in the bone marrow and abnormal fat metabolism [22,23]. In vitro experiments have confirmed that ethanol can upregulate the expression of PPARc mRNA in BMSCs and accelerate the differentiation of BMSCs into adipocytes, which ultimately leads to the proliferation and accumulation of a large number of adipocytes.…”

“…In vitro experiments have confirmed that ethanol can upregulate the expression of PPARc mRNA in BMSCs and accelerate the differentiation of BMSCs into adipocytes, which ultimately leads to the proliferation and accumulation of a large number of adipocytes. e bone cells in the femoral head could die due to lipid deposition and fatty degeneration [23,24]. Studies have reported that PPARc may be an important target gene that causes ANFH, and by blocking its expression, ethanol-induced adipocyte differentiation of BMSCs could be aberrated, and preventing the formation of ethanolic ANFH has significant application prospects [25][26][27].…”