The paper is aimed at developing technical and organizational measures to reduce the losses of electrical energy during its transmission via main and distribution electrical grids, in power transformers and electric power trans-mission lines. The focus of the study was on electrical grid modes in the Namangan Region of Uzbekistan (voltages of 220/110/35/10/6 kV), which were analyzed via technological calculation-based research methods using an equivalent circuit representing the linear circuit currently employed in the regional electric energy system. In addition, electrical grids were simulated using the software package “Program for calculating electrical grid modes” followed by the processing of calculation results by means of the Microsoft Excel package. The paper calculates electrical modes for the equivalent circuit of the regional electric energy system, as well as offering technical measures (installation of reactive power compensation devices; adjustment of transformation ratios in power transformers) aimed at adjusting voltage to improve electric power quality in terms of voltage deviations and lower power losses. Voltage deviations in most grid nodes were found to be inconsistent with GOST 32144-2013. Thus, in 35 kV, 10 kV, and 6 kV nodes, the largest underdeviation amounted to 12.45 kV, 3.26 kV, and 2.09 kV, respectively. For the placement of reactive power compensating devices having a total power of 67.82 MV∙Ar, 35 kV nodes were used; in addition, the values of transformer ratios at transformer substations (35–110 kV) were determined. Calculations indicate that the conducted activities can normalize voltage in the 35 kV, 10 kV, and 6 kV nodes while reducing power losses in the electrical grid by 9.35 MW. It is estimated that the proposed measures will be paid back in approximately three years. By means of compensating reactive power and adjusting transformer ratios, these measures can reduce electrical energy losses during transmission in the considered objects and maintain a given voltage level.