2016
DOI: 10.1186/s40662-016-0048-4
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Consideration of corneal biomechanics in the diagnosis and management of keratoconus: is it important?

Abstract: Keratoconus is a bilateral, non-inflammatory, degenerative corneal disease. The occurrence and development of keratoconus is associated with corneal thinning and conical protrusion, which causes irregular astigmatism. With the disruption of the collagen organization, the cornea loses its shape and function resulting in progressive visual degradation. Currently, corneal topography is the most important tool for the diagnosis of keratoconus, which may lead to false negatives among the patient population in the s… Show more

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Cited by 66 publications
(42 citation statements)
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“…The air puff test conducted by the Ocular Response Analyser (ORA; Reichert, Inc., Buffalo, NY), the CorVis-ST (Oculus Optikgerate GmbH, Wetzlar, Germany) [6]- [8] and others, is a noncontact tonometry method with direct interaction with the cornea used to estimate intraocular pressure that is necessary for glaucoma management [9]- [11]. Moreover, this test was proven to have a promising potential in corneal material characterisation and Keratoconus detection [12]- [15].Tonometry is based on a simple concept of applying a known load causing deformation in the cornea and relating this load to the pressure inside the eye. However, accuracy of intraocular pressure (IOP) estimation continues to be a challenge due to the effect of corneal parameters including corneal geometry and material properties [16], [17].…”
Section: Introductionmentioning
confidence: 99%
“…The air puff test conducted by the Ocular Response Analyser (ORA; Reichert, Inc., Buffalo, NY), the CorVis-ST (Oculus Optikgerate GmbH, Wetzlar, Germany) [6]- [8] and others, is a noncontact tonometry method with direct interaction with the cornea used to estimate intraocular pressure that is necessary for glaucoma management [9]- [11]. Moreover, this test was proven to have a promising potential in corneal material characterisation and Keratoconus detection [12]- [15].Tonometry is based on a simple concept of applying a known load causing deformation in the cornea and relating this load to the pressure inside the eye. However, accuracy of intraocular pressure (IOP) estimation continues to be a challenge due to the effect of corneal parameters including corneal geometry and material properties [16], [17].…”
Section: Introductionmentioning
confidence: 99%
“…Corneal biomechanical metrics are statistically significant between keratoconic and healthy corneas using both ORA 71,[75][76][77] (keratoconus showed lower CH and CRF value) and Corvis 71,[78][79][80] (keratoconus showed higher deformation amplitude), which could be useful to detect subclinical keratoconus. 81 Unfortunately, data provide for these devices have not proven to be a definitive keratoconus diagnostic value (able to differentiate between keratoconus, forme fruste and normal eyes) 71 because a substantial overlap exists with normal corneas, 82,83 and further research is necessary to obtain valid cut-off values to use in combination with more clinical data. 20,72,75,77,80,84,85 In summary, further clinical validation is necessary to inderstand the meaning of these biomechanical parameters obtainied with ORA and Corvis before they can be used in clinical practice.…”
Section: Biomechanical Devicesmentioning
confidence: 99%
“…Keratoconus corneas show abnormalities in biomechanical response when they are compared to normal corneas in ex-vivo studies. 69,70 However, in-vivo measurement of corneal biomechanics remains a difficult task, and just two commercially available instruments have been proposed; 1,71,72 the Ocular Response Analyzer ® (ORA; Reichert, New York, US) and the Corneal Visualization Scheimpflug Technology (Corvis ® ST;…”
Section: Biomechanical Devicesmentioning
confidence: 99%
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