The main aim of the current study is to analyze advantages and shortcomings of horizontal and vertical types of steam generator design. Design solutions and experience of operation of steam generators of horizontal type accepted in Russia and of vertical type applied by Westinghouse, Combustion Engineering, Siemens, Mitsubishi, Doosan were analyzed within the framework of the present study. It was established that steam generator equipment of horizontal type is characterized by disadvantages of design, technological and operational nature. Thus, horizontal steam generators with dimensions permissible for railroad transportation and, for VVER-1200 with reactor vessel diameter equal to 5 m, by water transport as well, have exhausted the possibilities for further significant increase of the per unit electric power. The demonstrated advantages of vertical-type steam generators are as follows: 1) absence of stagnant zones within the second cooling circuit; 2) uniformity of heat absorption efficiency of the heating surface that ensures improved conditions for moisture separation; 3) increased temperature drop with parameters of generated steam elevated by 0.3 – 0.4 MPa. Conclusion was made on the advisability of introduction of steam generators with vertical-type layout in the Russian nuclear power generation.