Based on the detailed analysis of the one-side milling theory of the spatial cam, an error comprehensive prediction model of the contour normal deviation is proposed in this paper by applying the spatial meshing theory, the rotation transformation of tensor and Newton’s iteration. A computer simulation example is presented, and the results show the error prediction model can disclosure and predict the law of influence effectively, that the tool and installation inaccuracy produce the contour normal error during the one-side processing of the spatial cam. Consequently, a scientific proof has been supplied to improve the precision and quality of the one-side milling of the globoidal indexing cam.