Consideration of the Tube Radial Distribution of the Carrier Solvents in a Capillary Tube under Laminar Flow Conditions and Computer Simulation

Jinno, Naoya; Masuhara, Yuji; Kobayashi, Tomoya; Tainaka, Naoya; Tanigawa, Yusuke; Hashimoto, Masahiko; Tsukagoshi, Kazuhiko

doi:10.2116/analsci.28.527

Cited by 10 publications

(6 citation statements)

References 13 publications

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“…3, is herein discussed. 20,40 The solution phase change was first evaluated in a batch vessel mode. A homogeneous solution, whose solvent composition ratio was near the boundary curve, was prepared, and was either cooled down to room temperature or pressurized.…”

Section: ·2 Phase Diagram Of Ternary Mixed Solvents Systemmentioning

confidence: 99%

“…The formation mechanism of the major phase, as the inner phase, in a ternary mixed-solvent solution, based on TRDP, was detailed in these reports. 20,40 Ternary systems with solvent composition ratios located on the tie line, in the phase diagram, were examined as carrier solutions to deepen our knowledge of the TRDP and TRDC systems. 41 The findings confirmed that the development of TRDP was based on solution phase separation from a homogeneous to a heterogeneous phase.…”

Section: ·2 Phase Diagram Of Ternary Mixed Solvents Systemmentioning

confidence: 99%

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Fundamental Research and Application of the Specific Fluidic Behavior of Mixed Solvents in a Microspace

Tsukagoshi

2014

ANAL. SCI.

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The author herein reviews a specific microfluidic behavior exhibited by mixed-solvent solutions in a microspace, coined as the tube radial distribution phenomenon (TRDP). The specific fluidic behavior was observed in the following solution systems: ternary water-hydrophilic/hydrophobic organic solvents, water-surfactant, water-ionic liquid, and fluorous/ organic solvents. When the mixed homogeneous solutions were delivered into a microspace under certain conditions, the solvent molecules were radially distributed in the microspace, generating inner and outer phases with a kinetic liquid-liquid interface. The TRDP was fundamentally evaluated by fluorescence microscopy, phase diagrams construction, and the elution behaviors of solutes in a capillary tube.

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Section: ·2 Phase Diagram Of Ternary Mixed Solvents Systemmentioning

confidence: 99%

Section: ·2 Phase Diagram Of Ternary Mixed Solvents Systemmentioning

confidence: 99%

Fundamental Research and Application of the Specific Fluidic Behavior of Mixed Solvents in a Microspace

Tsukagoshi

2014

ANAL. SCI.

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“…It is under non-control of the gravity and laminar-flow conditions. 17 The volume ratios of the upper and lower phases in a vessel that were estimated using the tie lines would not necessarily be equal to those of the inner and outer phases in TRDP. However, we consider that the volume ratios of the upper and lower phases in a vessel may be related to the formation of inner and outer phases in the TRDP.…”

Section: Effects Of Volume Ratios Of the Upper And Lower Phases In A mentioning

confidence: 99%

“…At the same time, the phase separation introduces TRDP, including inner and outer phases in a micro-flow where it is under non-control of gravity and laminar flow conditions. 17 During the TRDP and TRDC investigation, we considered that tie lines and the solubility curves on the phase diagram must be useful tools for investigation. In this study, various component ratios of the ternary mixed solvents on the tie lines were used as carrier solutions in the TRDC, and the obtained chromatograms and fluorescence photographs were considered together along with data provided through the tie lines and solubility curves.…”

Section: Introductionmentioning

confidence: 99%

Investigations into Tie Lines and Solubility Curves on Phase Diagrams in Open-Tubular Capillary Chromatography Using Ternary Mixed-Carrier Solvents

et al. 2012

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Open-tubular capillary chromatography using a ternary solvent mixture consisting of a water-hydrophilic-hydrophobic organic solvent as a carrier solution has been developed. When the ternary carrier solution is fed into the capillary tube, the carrier solvents are radially distributed and generate inner and outer phases in the tube. The outer phase functions as a pseudo-stationary phase in chromatography. In this study, investigations proceeded with reference to the tie lines and solubility curves on the phase diagram of the ternary mixed solvents. Model analytes, 1-naphthol and 2,6-naphthalenedisulfonic acid, were separated in this order with ternary water-acetonitrile-ethyl acetate solvent mixtures (organic solvent-rich solutions) that possessed various solvent compositions on the tie lines. In addition, fluorescence photographs of the dyes dissolved in the ternary solvents in the capillary tubes were observed with a fluorescence microscope-CCD camera system. It was found that the separation performance on the chromatograms and the phase formation observed in the fluorescence photographs were related to data provided through the tie lines and solubility curves on the phase diagram. The solvent compositions on the same tie line that gave different volume ratios of upper and lower phases in a vessel influenced the chromatographic separation, or the resolutions of the analytes, and also the inner and outer phase formation in the chromatography.

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“…Computer simulation 13,15 The microfluidic inverted flow in a Y-type microchannel was computer-simulated using both the volume of fluid method (VOF) and the species transport method (ST) (Fluent program; ANSYS, Inc., Canonsburg, USA). The VOF method simulates a multiphase flow with a liquid-liquid interface based on an assumption of the interface viscosity, density, surface tension, and contact angle.…”

Section: Response Of Microfluidic Inverted Flow To Phmentioning

confidence: 99%

Microfluidic Inverted Flow of Ternary Water/Hydrophilic/ Hydrophobic Organic Solvent Solution in a Y-Type Microchannel and a Proposal of the Response Microfluidic Analysis through the Experiment

et al. 2018

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Two solutions that are individually fed at the same flow rate into two separate microchannels of a microchip, combine to form a single channel (a Y-type microchannel). This flow is either parallel for immiscible solutions or initially parallel, but then becomes homogeneous through diffusion, for miscible solutions. However, a new type of microfluidic behavior in a Y-type microchannel that was neither parallel nor homogeneous flow has been observed using, for example, water/ acetonitrile (3:4.5, v/v) and acetonitrile/ethyl acetate (3.5:4, v/v) mixed solutions. Each mixed solution was marked with distinctive dyes and delivered at the same flow rate into a Y-type microchannel under laminar flow conditions. In the single channel, the two phases were initially observed to flow in parallel, but then apparently swapped to flow on the opposite wall while retaining parallel flow with a slight change in the components of the two phases. We have named this type of laminar flow "microfluidic inverted flow" for ternary water/hydrophilic/hydrophobic organic solvent mixed solutions. The inverted flow of a ternary water/acetonitrile/ethyl acetate system was examined in detail under various flow conditions. We also proposed a concept of response microfluidic analysis based on such microfluidic inverted flow.

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Consideration of the Tube Radial Distribution of the Carrier Solvents in a Capillary Tube under Laminar Flow Conditions and Computer Simulation

Cited by 10 publications

References 13 publications

Fundamental Research and Application of the Specific Fluidic Behavior of Mixed Solvents in a Microspace

Fundamental Research and Application of the Specific Fluidic Behavior of Mixed Solvents in a Microspace

Investigations into Tie Lines and Solubility Curves on Phase Diagrams in Open-Tubular Capillary Chromatography Using Ternary Mixed-Carrier Solvents

Microfluidic Inverted Flow of Ternary Water/Hydrophilic/ Hydrophobic Organic Solvent Solution in a Y-Type Microchannel and a Proposal of the Response Microfluidic Analysis through the Experiment

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