5G cellular communication, especially with its hugely available bandwidth provided by millimeter-wave, is a promising technology to fulfill the coming high demand for vast data rates. These networks can support new use cases such as Vehicle to Vehicle and augmented reality due to its novel features such as network slicing along with the mmWave multigigabit-per-second data rate. Nevertheless, 5G cellular networks suffer from some shortcomings, especially in high frequencies because of the intermittent nature of channels when the frequency rises. Non-line of sight state, is one of the significant issues that the new generation encounters. This drawback is because of the intense susceptibility of higher frequencies to blockage caused by obstacles and misalignment. This unique characteristic can impair the performance of the reliable transport layer widely deployed protocol, TCP, in attaining high throughput and low latency throughout a fair network. As a result, the protocol needs to adjust the congestion window size based on the current situation of the network. However, TCP is not able to adjust its congestion window efficiently, and it leads to throughput degradation of the protocol. This paper presents a comprehensive analysis of reliable end-to-end communications in 5G networks. It provides the analysis of the effects of TCP in 5G mmWave networks, the discussion of TCP mechanisms and parameters involved in the performance over 5G networks, and a survey of current challenges, solutions, and proposals. Finally, a feasibility analysis proposal of machine learning-based approaches to improve reliable end-to-end communications in 5G networks is presented. INDEX TERMS 5G, end-to-end reliability, mmWave, TCP ANNA CALVERAS AUGÉ was born in Barcelona, Spain, in 1969. She obtained a Ph.D. in Telecommunications Engineering from the Universitat Politècnica de Catalunya, Spain, in 2000. She is an associate professor at the mentioned University, at the Computer Networks Department, in the Wireless Networks Group (WNG). Her research interests and expertise areas comprise the design, evaluation, and optimization of communications protocols and architectures for cellular, wireless multihop networks, ad-hoc networks, wireless sensor networks, the Internet of Things, and application domains such as smart cities, building automation, satellite and emergency environments. She has been involved in several National and International research or technology transfer projects, and she has published in International and National conferences and journals.