With cities producing 80% of global GDP and housing more than half of the world's population (United Nations Human Settlements Programme UN-Habitat 2016, p. 264), urban processes now drive global flows of food, energy, and water, causing unprecedented disruptions to the planet's biogeochemical cycles. The procurement of food, energy, and water (FEW) often occurs outside urban boundaries, leading to geographic and sectoral interactions from local to global scales. These unforeseen and complex interactions degrade air and water quality, drive resource use, and exacerbate greenhouse gas emissions (GHGs). FEWprovisioning systems also have profound impacts on the economy and on human health and well-being. The linkages between the systems that supply FEW to cities and the outcomes related to human and planetary well-being are the focus of this special issue.The issue consists of nine articles, each of which presents emerging research on interconnected FEW systems as they relate to cities and regions. The papers are interdisciplinary, multiscalar, and cross-sectoral as they consider the effects of FEW interactions on the health of cities, their inhabitants, and the distant peoples and places from which they source their resources. As a set, including this introduction, the special issue covers the following topics: 1. Research to date on urban FEW systems and promising approaches 2. Urban agriculture and energy-water dynamics 3. Conventional agriculture and FEW dynamics 4. The energy foodprint of the American diet 5. Key areas for future researchIn the pages that follow, we briefly summarize each of the articles in this special issue, clustering them by topical areas. We conclude by identifying what we view as crucial research gaps needing further studies in the realm of urban FEW systems.