2015
DOI: 10.3389/fnins.2015.00269
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Considerations for resting state functional MRI and functional connectivity studies in rodents

Abstract: Resting state functional MRI (rs-fMRI) and functional connectivity mapping have become widely used tools in the human neuroimaging community and their use is rapidly spreading into the realm of rodent research as well. One of the many attractive features of rs-fMRI is that it is readily translatable from humans to animals and back again. Changes in functional connectivity observed in human studies can be followed by more invasive animal experiments to determine the neurophysiological basis for the alterations,… Show more

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Cited by 91 publications
(97 citation statements)
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References 170 publications
(286 reference statements)
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“…Therefore, anaesthesia reduces artefacts introduced by motion or physiological noise related to stress during fMRI scanning. However, it also induces adverse effects, such as the reduction of neuronal activity, disruption of the neurovascular coupling mechanism, respiratory suppression, disturbance of the cardiovascular system and regulation of the animal's body temperature (Tremoleda et al, 2012;Pan et al, 2015). These factors influence BOLD signals and confound the interpretations of fMRI experimental results.…”
Section: General Anaesthesia and Commonly Used Anaesthetic Regimens Fmentioning
confidence: 99%
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“…Therefore, anaesthesia reduces artefacts introduced by motion or physiological noise related to stress during fMRI scanning. However, it also induces adverse effects, such as the reduction of neuronal activity, disruption of the neurovascular coupling mechanism, respiratory suppression, disturbance of the cardiovascular system and regulation of the animal's body temperature (Tremoleda et al, 2012;Pan et al, 2015). These factors influence BOLD signals and confound the interpretations of fMRI experimental results.…”
Section: General Anaesthesia and Commonly Used Anaesthetic Regimens Fmentioning
confidence: 99%
“…However, it is a well-known vasodilatory agent that increases the baseline cerebral blood flow in a dose-dependent way, and hence may influence neurovascular interactions that could be detected by fMRI technique. Isoflurane also suppresses neural activity which confounds rs-fMRI results (Haensel et al, 2015;Pan et al, 2015). Like other general anaesthetics, the precise molecular mechanism of action of isoflurane is not clearly understood.…”
Section: General Anaesthesia and Commonly Used Anaesthetic Regimens Fmentioning
confidence: 99%
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