The behavior of steel frame buildings under progressive collapse conditions depends on a combination of several parameters, including the interplay between different collapse resistance mechanisms that are mobilized in different structural components. Previous studies have shown that the extent to which these mechanisms may contribute to progressive collapse resistance depends on the ability of the beam-column connections to undergo large inelastic deformations prior to reaching their deformation capacity limits. For this reason, and due to the important role of their flexural strength and tying capacity in the development of essential collapse resistance mechanisms, the response of beam-column connections is one of the most important features of progressive collapse performance. Based on the knowledge gained through previous studies on the mechanics of this problem, the role of these connections are critically reviewed in this paper by examining the results of several experimental studies that have been conducted during the past decade. The factors that may adversely affect progressive collapse resistance–such as the failure modes of certain connection types–are evaluated, and novel approaches to limiting these factors, which are currently under development, are reviewed. The assessment of these parameters leads to useful conclusions of practical significance while highlighting the aspects of these problems that need further study and understanding.