Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

Renaud, Jean‐François; Martinoli, Maria-Grazia

doi:10.3390/ijms20081883

Cited by 96 publications

(73 citation statements)

References 247 publications

(286 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…e neuroprotective effects of many polyphenols rely on its ability to permeate the blood-brain barrier (BBB) and directly scavenge pathological concentration of reactive oxygen and nitrogen species and chelate transition metal ions [6]. Distinctive polyphenols were shown to have different scavenging activities and abilities to activate key antioxidant enzymes in the brain, thus breaking the vicious cycle of oxidative stress and tissue damage [7,8]. Red-wine polyphenols with distinct structures have been documented to increase endothelial nitric oxide synthase (eNOS) while downregulating inducible nitric oxide synthase (iNOS) activity [9,10].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotection of Tropical Fruit Juice Mixture via the Reduction of iNOS Expression and CRH Level in β‐Amyloid‐Induced Rats Model of Alzheimer’s Disease

Ooi

Munawar

Rosli

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

This study aimed to determine the effects of tropical fruit juice mixture (pomegranate, white guava, and Roselle) on biochemical, behavioral, and histopathological changes of β-amyloid- (Aβ-) induced rats. Formulation 8 (F8) of tropical fruit juice mixture was chosen for this present study due to its high phenolic content and antioxidant capacity. Forty Wistar male rats were divided into five groups: dPBS (sham-operated control), dAβ (Aβ control), JPBS (F8 and PBS), JAβ (F8 and Aβ), and IBFAβ (ibuprofen and Aβ). F8 (5 ml/kg BW), and ibuprofen (10 ml/kg BW) was given orally daily for four weeks before the intracerebroventricular infusion of Aβ for two weeks. Histological analysis and neuronal count of hippocampus tissue in the Cornu Ammonis (CA1) region showed that supplementation with F8 was able to prevent Aβ-induced tissue damage and neuronal shrinkage. However, no significant difference in locomotor activity and novel object recognition (NOR) percentage was detected among different groups at day 7 and day 14 following Aβ infusion. Only effect of time differences (main effect of day) was observed at day 7 as compared to day 14, where reduction in locomotor activity and NOR percentage was observed in all groups, with F (1, 7) = 6.940, p<0.05 and F (1, 7) = 7.152, p<0.05, respectively. Besides, the MDA level of the JAβ group was significantly lower (p<0.01) than that of the dPBS group. However, no significant changes in SOD activity were detected among different groups. Significant reduction in plasma CRH level (p<0.05) and iNOS expression (p<0.01) in the brain was detected in the JAβ group as compared to the dAβ group. Hence, our current findings suggest that the tropical fruit juice mixture (F8) has the potential to protect the rats from Aβ-induced neurotoxicity in brain hippocampus tissue possibly via its antioxidant properties and the suppression of iNOS expression and CRH production.

show abstract

Section: Introductionmentioning

confidence: 99%

Neuroprotection of Tropical Fruit Juice Mixture via the Reduction of iNOS Expression and CRH Level in β‐Amyloid‐Induced Rats Model of Alzheimer’s Disease

Ooi

Munawar

Rosli

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…This study is in agreement to earlier report that main characteristic band of polysaccharide remain unchanged at different storage durations using FTIR and 2DIR spectroscopy 33 . Further, it is documented that plant polyphenols has anti-oxidative role in human health and diseases [34][35] . However, there is lack of studies on different storage conditions and duration on phenolic and flavonoid content of aqueous extract of Ganoderma lucidum.…”

Section: Resultsmentioning

confidence: 99%

Effect of Storage Temperature on Bio efficacy of Aqueous Extract of Ganoderma lucidum

2019

View full text Add to dashboard Cite

Stability testing is key requirement in the drug development process along with storage temperature which may deteriorate bio-constituents and efficacy of natural products. Aqueous extract of Ganoderma lucidum has revealed pharmacological effects against high altitude stressors and has potential for mitigating high altitude maladies. In the present study, the extract of Ganoderma lucidum was stored at different storage conditions such as room temperature, 4 °C and -20 °C for two year and qualitative and quantitative analysis of bio-constituents and bio-efficacy was carried out. No significant change was observed in any extract kept in different temperature conditions in terms of its polysaccharide, phenolic and flavonoids content. The extract kept at room temperature absorbed slight moisture in few samples but no change in overall polysaccharide, phenolic and flavonoids content was recorded. The moisture absorption problem was not observed in extracts stored at 4 °C and -20 °C. The bio-efficacy of the extract at room temperature, 4 °C or -20 °C were comparable to the freshly prepared extract and the data from the studies suggest that extract has good shelf life up to two year without loss of bio-efficacy. Overall, the extract retained its bio-efficacy for two years at different temperature storage conditions.

show abstract

“…Polyphenols are organic metabolites present in plants (Cory et al, 2018) and widely distributed in a variety of dietary sources (Aherne and O'Brien, 2002;Kim et al, 2009): fruits, vegetables, legumes, whole grains, seeds, nuts, extra virgin olive oil, red wine, coffee, tea, chocolate, herbs and spices (Rusconi and Conti, 2010;Fu et al, 2011;Regueiro et al, 2014;Vallverdú-Queralt et al, 2014, 2015Talhaoui et al, 2016). Despite their zero energy contribution (Ruiz et al, 2009) they act as bioactive dietary components associated with multiple positive health effects (An-Na et al, 2014;Ganesan and Xu, 2017;Szwajgier et al, 2017;Renaud and Martinoli, 2019) due to their regulating action on metabolism, chronic diseases and cell proliferation (Tressera-Rimbau et al, 2017). Polyphenols have a chemical structure with properties that make them the compounds with the greatest antioxidant action: o-diphenolic group, 2-3 double bond conjugated with the 4-oxo function and hydroxyl groups (OH) in positions 3 and 5 (Ruiz et al, 2009).…”

Section: Pterostilbene and Neurodegenerative Diseasesmentioning

confidence: 99%

Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

et al. 2020

View full text Add to dashboard Cite

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative stress (OS) associated with mitochondrial dysfunction and the deterioration of the electron transport chain has been shown to be a factor that contributes to neurodegeneration and plays a potential role in the pathogenesis of ALS. The regions of the central nervous system affected have high levels of reactive oxygen species (ROS) and reduced antioxidant defenses. Scientific studies propose treatment with antioxidants to combat the characteristic OS and the regeneration of nicotinamide adenine dinucleotide (NAD +) levels by the use of precursors. This review examines the possible roles of nicotinamide riboside and pterostilbene as therapeutic strategies in ALS.

show abstract

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

Cited by 96 publications

References 247 publications

Neuroprotection of Tropical Fruit Juice Mixture via the Reduction of iNOS Expression and CRH Level in β‐Amyloid‐Induced Rats Model of Alzheimer’s Disease

Neuroprotection of Tropical Fruit Juice Mixture via the Reduction of iNOS Expression and CRH Level in β‐Amyloid‐Induced Rats Model of Alzheimer’s Disease

Effect of Storage Temperature on Bio efficacy of Aqueous Extract of Ganoderma lucidum

Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

Contact Info

Product

Resources

About