Considerations in Designing and Using Standardized Diets in Toxicological Experiments

Rader, Jeanne I.

doi:10.1016/b978-0-12-332603-4.50012-3

Cited by 1 publication

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“…Methionine deficiency in methionine-marginal animals with prolonged (dietary) ACAP administration is indicated by decreased growth , McLean and Beales 1987, Reicks et al 1988, McLean et al 1989); inhi-S16 J. N. Hathcock bited protein synthesis, with decreases in plasma free cysteine; decreased excretion of creatinine and A'-methyl-nicotinamide ; and prolonged decreases in tissue GSH levels (Reicks etal. 1988, Reicks and Hathcock 1988b, 1989, Reicks etal. 1989.…”

Section: Alteration Of Methionine Functions and Requirements By Acetamentioning

confidence: 97%

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Nutritional toxicology: Basic principles and actual problems

Hathcock

1990

Food Additives and Contaminants

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Nutritional toxicology is a specialty that combines the backgrounds and research approaches of nutrition and toxicology. Many problems of substantial importance to health and food safety involve interactions of nutrition process and requirement with the effects of toxicological impact. Solution of these problems requires research that meets the procedural and design criteria of experimental nutrition and these of experimental toxicology. The relationships may be described in three basic categories: (1) influence of nutrition on toxicities; (2) influence of toxicants on nutrition; and (3) toxicities of nutrients. Trypsin inhibitor research, an example of diet impacting on toxicological response, illustrates the necessity of controlling nutritional composition aspects that can confound the results. Prolonged acetaminophen administration provides an example of the effects of toxicants on nutritional requirement and function which could be important for persons with marginal sulphur amino acid intake.

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Section: Alteration Of Methionine Functions and Requirements By Acetamentioning

confidence: 97%

“…Well-defined, standardized diets are needed to reduce variability in dose-response relationships and to improve the toxicological database for risk assessment and safety evaluation (Rader 1989). In general, natural-ingredient diets and those with high nutrient content produce relative resistance to the effects of xenobiotics.…”

Section: J N Hathcockmentioning

confidence: 99%

Nutritional toxicology: Basic principles and actual problems

Hathcock

1990

Food Additives and Contaminants

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show abstract

Considerations in Designing and Using Standardized Diets in Toxicological Experiments

Cited by 1 publication

References 42 publications

Nutritional toxicology: Basic principles and actual problems

Nutritional toxicology: Basic principles and actual problems

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