Considerations in the treatment of early osteoarthritis

Arabelovic, Senada; McAlindon, Timothy E.

doi:10.1007/s11926-005-0006-y

Cited by 11 publications

(9 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recent success of strontium ranelate as a disease-modifying agent for OA provides the first clear evidence that this hypothesis has been confirmed [40]. Some other bone-targeting agents have been assessed as OA therapeutics, including bisphosphonates [41,42], calcitonin [43] and vitamin D [44]. These bone-acting agents are unlikely to be effective in late stages of OA, when remodeling is already suppressed.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide expression profiles of subchondral bone in osteoarthritis

et al. 2013

View full text Add to dashboard Cite

IntroductionThe aim of this study was to evaluate, for the first time, the differences in gene expression profiles of normal and osteoarthritic (OA) subchondral bone in human subjects.MethodsFollowing histological assessment of the integrity of overlying cartilage and the severity of bone abnormality by micro-computed tomography, we isolated total RNA from regions of interest from human OA (n = 20) and non-OA (n = 5) knee lateral tibial (LT) and medial tibial (MT) plateaus. A whole-genome profiling study was performed on an Agilent microarray platform and analyzed using Agilent GeneSpring GX11.5. Confirmatory quantitative reverse-transcription polymerase chain reaction (qRT-PCR) analysis was performed on samples from 9 OA individuals to confirm differential expression of 85 genes identified by microarray. Ingenuity Pathway Analysis (IPA) was used to investigate canonical pathways and immunohistochemical staining was performed to validate protein expression levels in samples.ResultsA total of 972 differentially expressed genes were identified (fold change ≥ ± 2, P ≤0.05) between LT (minimal degeneration) and MT (significant degeneration) regions from OA samples; these data implicated 279 canonical pathways in IPA. The qRT-PCR data strongly confirmed the accuracy of microarray results (R2 = 0.58, P <0.0001). Novel pathways were identified in this study including Periostin (POSTN) and Leptin (LEP), which are implicated in bone remodeling by osteoblasts.ConclusionsTo the best of our knowledge, this study represents the most comprehensive direct assessment to date of gene expression profiling in OA subchondral bone. This study provides insights that could contribute to the development of new biomarkers and therapeutic strategies for OA.

show abstract

Section: Discussionmentioning

confidence: 99%

Genome-wide expression profiles of subchondral bone in osteoarthritis

et al. 2013

View full text Add to dashboard Cite

show abstract

“…4 The same authors have postulated a protective mechanism of vitamin D against knee osteoarthritis, due to increased nitric oxide synthesis. 8 The possible protective effect of vitamin D on knee osteoarthritis progression has led to a recommendation for vitamin D supplementation in the treatment of early knee osteoarthritis, 6 particularly in patients with low bone mineral density. 14 However, while vitamin D levels are commonly low in knee osteoarthritis patients, there is not a linear correlation between these levels and osteoarthritis grade or functional incapacitation.…”

Section: Discussionmentioning

confidence: 99%

“…5 It has been suggested that vitamin D supplementation should be included in the treatment algorithm of early knee osteoarthritis, as it might be preferable to long-term anti-inflammatory intake. 6 Vitamin D supplementation appears to be important in improving prognosis of both osteoporosis and osteoarthritis according to some reports. 7 The current cohort evaluation was performed in order to assess whether the evaluation of vitamin D levels is imperative in the evaluation of patients with severe knee osteoarthritis in an Israeli population.…”

Section: Introductionmentioning

confidence: 99%

Lower vitamin D levels in knee arthroplasty candidates as compared with lumbar spondylosis patients

Yassin

Garti

Khatib

et al. 2015

Journal of Arthroscopy and Joint Surgery

View full text Add to dashboard Cite

Available online xxx Keywords:Vitamin D OsteoarthritisLumbar spondylosis a b s t r a c t Purpose: Low Vitamin D levels are common in adult Middle-Eastern populations as well as in patients with knee osteoarthritis. The current study was designed in order to assess whether vitamin D levels are different in patients with two types of osteoarthritis.Methods: A prospective, non-randomized observational study of two groups was performed.Patients with severe knee osteoarthritis requiring knee replacement (n ¼ 38) were compared to a control group of osteoarthritic patients suffering from lumbar spondylosis (n ¼ 24). KOOS pain subscale scores were used to evaluate knee related pain, and imaging studies were used to define the arthritic process of the knees. Lumbar CT scans were available for most patients. Results:The study results indicate that vitamin D insufficiency is common in both populations. However vitamin D levels were lower in the knee osteoarthritic patients than in the lumbar spondylosis patients. Low vitamin D levels correlate with worse pain in arthroplasty candidates but not in lumbar spine osteoarthritis patients. Conclusions:The current study appears to indicate that vitamin D abnormalities are common in both types of osteoarthritis evaluated but are more severe in knee arthroplasty candidates and in this group are related to the pain severity levels.Please cite this article in press as: Yassin M, et al., Lower vitamin D levels in knee arthroplasty candidates as compared with lumbar spondylosis patients, Journal of Arthroscopy and Joint Surgery (2015), http://dx.

show abstract

“…Among various reasons, these knee disorders are attributed to obesity-related problems among the population. Knee replacement or knee arthroplasty is a procedure for treating osteoarthritis by replacing the worn cartilage between the knee joints with an artificial implant component (Arabelovic & McAlindon, 2005;Harman et al, 2014). This method has been proven to effectively relieve pain and regain normal knee movement in patients suffering from this disorder.…”

Section: Introductionmentioning

confidence: 99%

Jig Prototype for Computer-Assisted Total Knee Replacement and Its Flow Simulation

Sulong¹,

Arifin

Harun³

2016

IJTech

View full text Add to dashboard Cite

This paper discusses the design and development of a prototype of a knee surgery cutting jig, the jig holder, and the jig injection mold by Rapid Prototyping (RP). The aim of this study is to design a jig and a jig holder that allow surgeons to correctly, precisely, and consistently perform knee replacement surgery. The design concept for the surgery jig and jig holder was selected using the Pugh method with medical-grade 316L stainless steel for material fabrication. A rapid prototype model was built directly from its CAD model in stereo lithography (STL) format by using the Fused Deposition Method (FDM). MasterCAM and Moldflow simulation were performed to generated G-codes and a possibility of jig fabrication using Metal Injection Molding (MIM), respectively. The Moldflow result provided an enhanced interpretation of the injection mold design. A conceptual mold design was again developed by the FDM. The prototype of the cutting jig and its holder underwent a machining process. The prototype was then tested on dummy bones to determine the functional performance and efficiency of the said prototype. Results indicated an increase in cutting accuracy and cutting time compared with computer-assisted total knee surgery without the jig system.

show abstract

Considerations in the treatment of early osteoarthritis

Cited by 11 publications

References 43 publications

Genome-wide expression profiles of subchondral bone in osteoarthritis

Genome-wide expression profiles of subchondral bone in osteoarthritis

Lower vitamin D levels in knee arthroplasty candidates as compared with lumbar spondylosis patients

Jig Prototype for Computer-Assisted Total Knee Replacement and Its Flow Simulation

Contact Info

Product

Resources

About