Considerations on manufacturing principles of a synthetic burn dressing: A review

Abstract

This review presents various considerations on the construction of a synthetic burn dressing, based mainly on collagen protein. Membranous wound covers are compared with sponge-felt types, monocomponental with composite. The importance of collagen crosslinking agent and the nonextractibility of any component from the dressing material are discussed. According to the type of the burn the dressing should be used dry or wet, plain or medicated, and changed often to reduce substantially the presence of necrotic tissue, inflammatory cell of the granulation tissue, and bacterial contamination.

Evaluation of different chemical methods for cros-linking collagen gel, films and sponges

“…Comparative analysis of pericardium treated with GTA and with the acyl azide methods demonstrated the excellent cytocompatibility (endothelial cells) of DPPA-treated biomaterials [10]. Other agents used frequently are diisocyanates and carbodiimides [11][12][13][14][15][16][17][18].…”

Methylcellulose cell culture as a new cytotoxicity test system for biomaterials

“…However, HDSC may be suspected of cytotoxic effects, because of the tanning agent used. HMDIC as tanning agent has been used by others for other types of collagen [2,[16][17][18][19]. Although HMDIC was reported to be a more adequate tanning agent than glutaraldehyde with respect to cytotoxicity [2,15,18,19], Ulreich et al [2] observed 22% inhibition in 3H-thymidine incorporation, when testing an extract of a collagen sponge tanned with HMDIC.…”

“…HMDIC as tanning agent has been used by others for other types of collagen [2,[16][17][18][19]. Although HMDIC was reported to be a more adequate tanning agent than glutaraldehyde with respect to cytotoxicity [2,15,18,19], Ulreich et al [2] observed 22% inhibition in 3H-thymidine incorporation, when testing an extract of a collagen sponge tanned with HMDIC. Cytotoxic effects of diisocyanates have been repeatedly reported [20][21][22][23], and 1,6-diaminohexane, which is a cytotoxic hydrolysis product of HMDIC [24][25][26], may be released from collagens tanned with HMDIC.…”

Biomedical Applications of Interpenetrating Polymer Network System

“…They were mainly used in wound dressings and hemostyptics and also very helpful in the treatment of severe burns [87]. The advantages of collagen area) Their capacity to easily take up large quantities of tissue exudates and provide smooth adherence to the wet wound bed with preservation of moist climate.…”