Considerations on pathophysiology of primary dysmenorrhea under the light of alterations in complete blood count parameters

Abstract

The present study strives to evaluate how the components of complete blood count are altered in women with primary dysmenorrhea. This is a cross-sectional analysis of 155 women with primary dysmenorrhea and 155 women without dysmenorrhea. The primary dysmenorrhea and control groups were matched with respect to age and body mass index. When compared with the controls, the women with primary dysmenorrhea had a significantly younger menarche age, longer menstrual duration, higher leukocyte counts, higher neutrophil counts, and elevated MPV values (p=0.010, p=0.022, p=0.014, p=0.011 and p=0.04 respectively). The logistic regression analysis demonstrated that women with primary dysmenorrhea were more likely to have a younger menarche age (OR=2.14, 95% CI=0.971-3.346, p=0.018), longer menstrual duration (OR=1.91, 95% CI=0.988-2.308, p=0.044), higher leukocyte counts (OR= 2.90, 95% CI=1.040-3.788, p=0.007), and elevated MPV values (OR=3.17, 95% CI=2.056-9.128, p=0.001). The sensitivity and specificity of this model were 84.6% and 77.3%, respectively. Leukocytosis and increased MPV are might be associated with the inflammatory and vasoconstrictory pathogenesis of primary dysmenorrhea, but this result should be confirmed in the future researches.

Hubungan antara Frekuensi Konsumsi Junk Food dan Status Gizi dengan Kejadian Dysmenorrhea pada Siswi Sekolah Menengah Pertama IT Ar-Rayyan Surabaya

“…Hal ini dapat dikarenakan asupan lemak merupakan prekursor pembentukan prostaglandin yang berperan dalam menyebabkan dysmenorrhea (Mesele et al, 2022;Huang et al, 2022;Mohammadi et al, 2022). Prostaglandin ini menyebabkan meningkatnya kontraksi miometrium dan vasokontriksi yang mengakibatkan terjadinya iskemia uterus sehingga menimbulkan rasa nyeri (Bernardi et al, 2017).…”

Effect of curcumin on inflammatory biomarkers and iron profile in patients with premenstrual syndrome and dysmenorrhea: A randomized controlled trial

“…It has been shown that serum hsCRP levels vary during the menstrual cycle in PMS women together with physical and mood manifestations, which advocates the contribution of low‐grade inflammation in the etiology of PMS (Puder et al, 2006 ). Several studies have reported that serum hsCRP, WBC, MPV and NLR are significantly associated with the presence of PMS and dysmenorrhea (Bahrami, Bahrami‐Taghanaki, et al, 2020 ; Bodur et al, 2017 ).…”