Considerations on the animal model and the biomechanical test arrangements for assessing the osseous integration of orthopedic and dental implants

Frosch, Stephan; Buchhorn, Gottfried

doi:10.1016/j.mex.2021.101352

Cited by 8 publications

(3 citation statements)

References 24 publications

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“…The rabbit has Haversian systems similar to those of humans and has the advantages of easy access to the surgical site and fast bone metabolism and a short lifespan of the experimental animal, allowing analysis of the osseointegration period within a short time [ 16 ]. In this study, we did not apply a load to implants placed in the rabbit tibia, and the healing period of 4 weeks after the placement of implants was suitable to simulate the early osseointegration stage of the healing period in humans [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Platelet-rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfaces

et al. 2022

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Purpose Osseointegration consists of bidirectional bone formation around modified implant surfaces by contact osteogenesis and distance osteogenesis. This study tested whether contact osteogenesis on the surface of a modified titanium (Ti) implant is stimulated by cytokines in the blood. Methods In the first two types of experiments, sandblasted, large-grit, acid-etched Ti implants and turned Ti tubes were inserted into rabbit tibiae. To exclude the influence of distance osteogenesis, the tubes were inserted into the tibiae, and implants were placed inside the tubes. In a third type of experiment, the implants and tubes were inserted into the rabbit tibiae, and platelet-rich plasma (PRP) or recombinant human bone morphogenetic protein-2 (rhBMP-2) was applied topically. Four weeks after implantation, undecalcified specimens were prepared for histomorphometry. Bone-to-implant contact (BIC) and bone area per tissue (BA) were measured, and the data were analysed using one-way ANOVA at a significance level of 0.05. Results When the response of bone to Ti tubes with implants was compared to that without implants (first experiment), little bone formation was found inside the tubes. The mean BIC of implant specimens inside the tubes was 21.41 ± 13.81% in a second experiment that evaluated bone responses to implants with or without Ti tubes. This mean BIC value was significantly lower than that in the implant-only group (without tubes) (47.32 ± 12.09%, P = 0.030). The third experiment showed that rhBMP-2 significantly increased contact osteogenesis on the implant surface, whereas PRP had no effect (mean BIC: 66.53 ± 14.06% vs. 16.34 ± 15.98%, P = 0.004). Conclusions Platelet-rich plasma alone is unable to trigger contact osteogenesis on the modified titanium implant surface.

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Section: Discussionmentioning

confidence: 99%

Platelet-rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfaces

et al. 2022

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“…[ [43][44][45][46][47][48][49][50][51] Fatigue strength Affects the service life of the implant. [52][53][54][55][56][57][58][59] Degradation Affects osseointegration [60-68] Avoids peri-implantitis etc.…”

Section: Elastic Modulusmentioning

confidence: 99%

“…Implants with good biomechanical properties play an essential role in the long-term success rate of implants [46]. After implantation, the implant forms a bone-binding interface with the surrounding bone tissue [47].…”

Section: Elastic Modulusmentioning

confidence: 99%

Mechanical and Biological Properties of Titanium and Its Alloys for Oral Implant with Preparation Techniques: A Review

Wu,

Chen,

Kong

et al. 2023

Materials

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Dental implants have revolutionised restorative dentistry, offering patients a natural-looking and durable solution to replace missing or severely damaged teeth. Titanium and its alloys have emerged as the gold standard among the various materials available due to their exceptional properties. One of the critical advantages of titanium and its alloys is their remarkable biocompatibility which ensures minimal adverse reactions within the human body. Furthermore, they exhibit outstanding corrosion resistance ensuring the longevity of the implant. Their mechanical properties, including hardness, tensile strength, yield strength, and fatigue strength, align perfectly with the demanding requirements of dental implants, guaranteeing the restoration’s functionality and durability. This narrative review aims to provide a comprehensive understanding of the manufacturing techniques employed for titanium and its alloy dental implants while shedding light on their intrinsic properties. It also presents crucial proof-of-concept examples, offering tangible evidence of these materials’ effectiveness in clinical applications. However, despite their numerous advantages, certain limitations still exist necessitating ongoing research and development efforts. This review will briefly touch upon these restrictions and explore the evolving trends likely to shape the future of titanium and its alloy dental implants.

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Calibration of Aseptic Loosening Simulation for Coatings Osteoinductive Effect

Baroni,

Oliviero,

La Mattina

et al. 2024

Ann Biomed Eng

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The risk of aseptic loosening in cementless hip stems can be reduced by improving osseointegration with osteoinductive coatings favoring long-term implant stability. Osseointegration is usually evaluated in vivo studies, which, however, do not reproduce the mechanically driven adaptation process. This study aims to develop an in silico model to predict implant osseointegration and the effect of induced micromotion on long-term stability, including a calibration of the material osteoinductivity with conventional in vivo studies. A Finite Element model of the tibia implanted with pins was generated, exploiting bone-to-implant contact measures of cylindrical titanium alloys implanted in rabbits’ tibiae. The evolution of the contact status between bone and implant was modeled using a finite state machine, which updated the contact state at each iteration based on relative micromotion, shear and tensile stresses, and bone-to-implant distance. The model was calibrated with in vivo data by identifying the maximum bridgeable gap. Afterward, a push-out test was simulated to predict the axial load that caused the macroscopic mobilization of the pin. The bone-implant bridgeable gap ranged between 50 μm and 80 μm. Predicted push-out strength ranged from 19 N to 21 N (5.4 MPa–3.4 MPa) depending on final bone-to-implant contact. Push-out strength agrees with experimental measurements from a previous animal study (4 ± 1 MPa), carried out using the same implant material, coated, or uncoated. This method can partially replace in vivo studies and predict the long-term stability of cementless hip stems.

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Considerations on the animal model and the biomechanical test arrangements for assessing the osseous integration of orthopedic and dental implants

Cited by 8 publications

References 24 publications

Platelet-rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfaces

Platelet-rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfaces

Mechanical and Biological Properties of Titanium and Its Alloys for Oral Implant with Preparation Techniques: A Review

Calibration of Aseptic Loosening Simulation for Coatings Osteoinductive Effect

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