Considérations portant sur l’écrasement des comprimés en gériatrie

Fodil, Mohammed Sadek; Fillette, Amélie; Trivalle, C.

doi:10.1016/j.npg.2012.07.013

Cited by 8 publications

(2 citation statements)

References 2 publications

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“…Crushing a prolonged release tablet could seriously compromise the pharmacokinetics and/or pharmacodynamics of the product [ 10 ]. Such unlicensed use may alter the efficiency of the treatment, or even induce toxic effects for the patients as well as for the caregivers [ 4 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Acceptability in the Older Population: The Importance of an Appropriate Tablet Size

Vallet¹,

Michelon

Orlu³

et al. 2020

Pharmaceutics

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Presenting many advantages, solid oral dosage forms (SODFs) are widely manufactured and frequently prescribed in older populations regardless of the specific characteristics of patients. Commonly, patients with dysphagia (swallowing disorders) experience difficulties taking SODFs, which may lead to non-adherence or misuse. SODF characteristics (e.g., size, shape, thickness) are likely to influence swallowability. Herein, we used the acceptability reference framework (the ClinSearch acceptability score test (CAST))—a 3D-map juxtaposing two acceptability profiles—to investigate the impact of tablet size on acceptability. We collected 938 observer reports on the tablet intake by patients ≥65 years in hospitals or care homes. As we might expect, tablets could be classified as accepted in older patients without dysphagia (n = 790), while not in those with swallowing disorders (n = 146). However, reducing the tablet size had a significant impact on acceptability in this subpopulation: tablets <6.5 mm appeared to be accepted by patients with swallowing disorders. Among the 309 distinct tablets assessed in this study, ranging in size from 4.7 to 21.5 mm, 83% are ≥6.5 mm and consequently may be poorly accepted by institutionalized older people and older inpatients suffering from dysphagia. This underlines the need to develop and prescribe medicines with the best adapted characteristics to reach an optimal acceptability in targeted users.

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Section: Introductionmentioning

confidence: 99%

Acceptability in the Older Population: The Importance of an Appropriate Tablet Size

Vallet¹,

Michelon

Orlu³

et al. 2020

Pharmaceutics

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“…Repackaging enables optimal identification of medications [1] while the modification makes the administration easier or possible in compliance with a medical prescription [2]. These are consistent practices carried out by healthcare professionals, caregivers or even family aids, out hospital.…”

Section: Introductionmentioning

confidence: 99%

Risks for Workers Handling Solid Oral Doses: Development of a Tool to Improve Personal Protection

Sgarioto

Aupee

Simon

et al. 2016

Pharmaceutical Technology in Hospital Pharmacy

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AbstractHandling of pharmaceutical specialities is required before its distribution or administration. Unpackaging and repackaging solid oral doses (SOD) in pharmacy settings; crushing, pills fragmenting or capsules opening inside care units may expose nurses and pharmacy dispensers to chemical contamination according to three recent North American studies. In the absence of a regulatory framework the application of the “principle of precaution” implies at first an analysis of the medication circuit and then the implementation of protective measures to prevent healthcare workers from contamination. Comparison of professional recommendations published in other countries allowed us to select a group of protective methods. We gathered these technical and organisational methods to compose a matrix of recommendations intended to hospital staff involved in SOD handling. This tool aims to improve the development of good manufacturing practices (GMP). It combines the issue of personal protection with other criteria such as quality, efficiency and safety of a medication.

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Résultats de l’enquête réalisée par le groupe gériatrie de la Société française de pharmacie clinique : intérêt d’un référentiel unique pour les pratiques d’écrasement des comprimés et/ou ouverture des gélules pour administrer les formes orales sèches

Lepelletier

Bornet

Bezel³

et al. 2014

cah. année gerontol.

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Considérations portant sur l’écrasement des comprimés en gériatrie

Cited by 8 publications

References 2 publications

Acceptability in the Older Population: The Importance of an Appropriate Tablet Size

Acceptability in the Older Population: The Importance of an Appropriate Tablet Size

Risks for Workers Handling Solid Oral Doses: Development of a Tool to Improve Personal Protection

Résultats de l’enquête réalisée par le groupe gériatrie de la Société française de pharmacie clinique : intérêt d’un référentiel unique pour les pratiques d’écrasement des comprimés et/ou ouverture des gélules pour administrer les formes orales sèches

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