Considerations, possible contraindications, and potential mechanisms for deleterious effect in recreational and athletic use of selective androgen receptor modulators (SARMs) in lieu of anabolic androgenic steroids: A narrative review

Machek, Steven B.; Cardaci, Thomas D.; Wilburn, Dylan T.; Willoughby, Darryn S.

doi:10.1016/j.steroids.2020.108753

Cited by 30 publications

(35 citation statements)

References 116 publications

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“…In an attempt to mitigate the risks associated with the administration of testosterone and other AAS in pathologies that result in the loss of muscle mass and function, as well as in hormone replacement therapies, SARMs were developed, which have a targeted therapeutic effect through binding to the androgen receptor in muscle and bone tissues (Thevis and Schänzer, 2018). The pharmacophores present in SARMs have an unprecedented potential for chemical modifications, these include steroidal substances such as testosterone itself and non-steroids such as aniline, aryl-propionamides, benzimidazole, bicylclic hydantoins, bridged tricyclics, diarylaniline, indole, quinolones, tetrahydroquinolones, tricyclics and pyrazoline derivatives (Machek et al, 2020).…”

Section: Selective Androgen Receptor Modulatorsmentioning

confidence: 99%

Suplementos deportivos: ¿riesgo a la salud?

et al. 2022

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Los suplementos deportivos son una categoría de los suplementos alimenticios que en los últimos años no solo ha incrementado en cantidad y disponibilidad, sino también en el número de nuevos productos. Deportistas de todos los niveles se interesan en el consumo de suplementos que son útiles para incrementar la ganancia de masa muscular convirtiendo así el consumo de estos productos en una práctica común. Desafortunadamente existen algunos productos que en realidad son sustancias dopantes que son ofertadas como suplementos deportivos, por otra parte ciertos suplementos deportivos pueden contener sustancias con actividad farmacológica o sus análogos no declarados en sus ingredientes probablemente para potenciar de manera efectiva los beneficios que estos productos aseguran, exponiendo a los consumidores a un riesgo potencial significativo a la salud, sobre todo a aquellos que no están familiarizados con los suplementos deportivos. Es importante que los profesionales de la salud tengan el conocimiento de las posibles implicaciones por el consumo de ciertos productos ofertados en el mercado de la nutrición deportiva al momento de evaluar a sus pacientes para una variedad de patologías.

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Section: Selective Androgen Receptor Modulatorsmentioning

confidence: 99%

Suplementos deportivos: ¿riesgo a la salud?

et al. 2022

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“…It has been suggested that SARM use has been increased recently, although factual evidence has been lacking [ 18 ]. Users of SARM mainly claim that SARM are safe; however, hardly any clinical studies support the efficacy and safety of such experimental drugs [ 19 ]. In fact, in 2017 the US Food and Drug Administration (FDA) issued a public statement that SARM were being included in supplements and that these compounds posed an increased risk for heart attack, stroke, and liver damage [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to AAS, there are some indications, mainly based on analysis of online sales of doping substances [ 16 ], that gym users also started using more experimental drugs, such as selective androgen receptor modulators (SARM) [ 17 , 18 ]. However, little is known about the efficacy and safety of the use of SARM in humans [ 19 ]. Regardless, both SARM and AAS, often termed together as ‘image and performance-enhancing drugs,’ are predominantly used to increase muscularity and modify appearance [ 9 , 10 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Social Media, Body Image and Resistance Training: Creating the Perfect ‘Me’ with Dietary Supplements, Anabolic Steroids and SARM’s

et al. 2021

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Background Few studies have assessed the use of dietary supplements, anabolic androgenic steroids (AAS) and selective androgen receptor modulators (SARM) in male gym users. The comparison of physical appearance with others on social media and the exposure to fitness-related content on social media (i.e., image-centric social media use) may have a profound role in using these compounds due to its role in creating negative body images in male gym users. Objective Provide contemporary data on the use of dietary supplements, AAS and SARM among young male gym users, and test the hypothesis that social media is associated with the use of dietary supplements, AAS and SARM, as a result of a negative body image. Methods In this cross-sectional study, conducted in the Netherlands, male gym users (N = 2269; 24 ± 6 years) completed an online questionnaire including self-reported measures regarding resistance training participation, image-centric social media use, dietary supplement intake, and body image. The prevalence of AAS and SARM use was assessed with randomized response, a technique to ask sensitive questions indirectly. Results Of all participants, 83% used ergogenic dietary supplements (mainly protein and creatine), and an estimated 9 versus 2.7% had ever used AAS versus SARM. Image-centric social media use was positively associated with the use of dietary supplements (r = .26; p < 0.01) and AAS (p < 0.05), but not SARM. Image-centric social media use was associated with a more dissatisfied body image (r = .34; p < 0.01). Body image did not mediate the relationship between image-centric social media use and the use of doping compounds. Conclusions The use of dietary supplements in young male gym users is exorbitant, with the use of AAS and SARM being substantial. Image-centric social media use is positively associated with the use of dietary supplements and AAS.

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“…Voor zover we weten vinden de productie, de marketing en het gebruik van SARMs grotendeels plaats buiten het traditionele circuit waarin anabole steroïden worden geproduceerd, vermarkt en geconsumeerd. Er is dus sprake van een nieuw dopingmilieu, dat zich naast het bestaande circuit manifesteert [3]. Bij de Dopingautoriteit zijn meldingen binnengekomen van gezondheidswerkers, die rapporteerden dat vooral jongeren deze middelen als alternatief gebruiken voor anabole steroïden.…”

Section: Gebruikunclassified

SARMs: een nieuw gezondheidsprobleem in fitness en bodybuilding

Koert

Zwaagstra²,

Nagtegaal

et al. 2021

TSG Tijdschr Gezondheidswet

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SamenvattingIn het Nederlandse fitness- en sportschoolmilieu wint een nieuwe groep dopingmiddelen snel aan populariteit. In het jargon van de sporters in dit circuit heten ze SARMs, een afkorting voor Selective Androgen Receptor Modulators. SARMs zijn experimentele middelen die spiergroei en vetverlies moeten bewerkstelligen, die nog in de ontwikkelingsfase zijn, nog niet zijn goedgekeurd voor gebruik door artsen, maar al wel vrijelijk verkrijgbaar zijn via webwinkels. SARMs zijn verboden in de sport en staan op de dopinglijst. De farmabedrijven die deze stoffen hebben ontwikkeld, hebben in een aantal gevallen hun trials stopgezet nadat er zorgwekkende bijwerkingen aan het licht kwamen. Desondanks bieden wereldwijd honderden webwinkels deze experimentele middelen aan, en vertellen diverse ‘experts’ op sociale media dat SARMs volstrekt veilig zijn. De verkrijgbaarheid van deze middelen geeft aanleiding tot zorg.

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Considerations, possible contraindications, and potential mechanisms for deleterious effect in recreational and athletic use of selective androgen receptor modulators (SARMs) in lieu of anabolic androgenic steroids: A narrative review

Cited by 30 publications

References 116 publications

Suplementos deportivos: ¿riesgo a la salud?

Suplementos deportivos: ¿riesgo a la salud?

Social Media, Body Image and Resistance Training: Creating the Perfect ‘Me’ with Dietary Supplements, Anabolic Steroids and SARM’s

SARMs: een nieuw gezondheidsprobleem in fitness en bodybuilding

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