Consistency and accuracy of diagnostic cancer codes generated by automated registration: comparison with manual registration

Tagliabue, Giovanna; Maghini, Anna; Fabiano, Sabrina; Tittarelli, Andrea; Frassoldi, Emanuela; Costa, Enrica; Nobile, Silvia; Codazzi, T; Crosignani, Paolo; Tessandori, Roberto; Contiero, Paolo

doi:10.1186/1478-7954-4-10

Cited by 15 publications

(8 citation statements)

References 15 publications

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“…This served as an additional check that case details were correct, and provided the following additional information: BMI (kg/m 2 ), disease stage (TNM), menopausal status at diagnosis, and tumour estrogen and progesterone receptor data. A series of algorithms included in the Open Registry software [20] was then applied to ascertain whether any adverse breast cancer events for these cases had been registered in the hospital discharge database of the Region of Lombardy from 1996 to 2009. Cases with an adverse event were then hand-searched in clinical records (Step 4, Figure 1) to confirm the event and obtain details (locoregional recurrence, distant metastasis, death).…”

Section: Methodsmentioning

confidence: 99%

Fasting blood glucose and long-term prognosis of non-metastatic breast cancer: a cohort study

Contiero

Berrino

Tagliabue

et al. 2013

Breast Cancer Res Treat

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High circulating glucose has been associated with increased risk of breast cancer. There may also be a link between serum glucose and prognosis in women treated for breast cancer. We assessed the effect of peridiagnostic fasting blood glucose and body mass index (BMI) on long-term breast cancer prognosis. We retrospectively investigated 1261 women diagnosed and treated for stage I-III breast cancer at the National Cancer Institute, Milan, in 1996, 1999, and 2000. Data on blood tests and follow-up were obtained by linking electronic archives, with follow-up to end of 2009. Multivariate Cox modelling estimated hazard ratios (HR) with 95% confidence intervals (CI) for distant metastasis, recurrence and death (all causes) in relation to categorized peridiagnostic fasting blood glucose and BMI. Mediation analysis investigated whether blood glucose mediated the BMI-breast cancer prognosis association. The risks of distant metastasis were significantly higher for all other quintiles compared to the lowest glucose quintile (reference <87 mg/dL) (respective HRs: 1.99 95%CI 1.23-3.24, 1.85 95%CI 1.14-3.0, 1.73 95%CI 1.07-2.8, and 1.91 95%CI 1.15-3.17). The risk of recurrence was significantly higher for all other glucose quintiles compared to the first. The risk of death was significantly higher than reference in the second, fourth and fifth quintiles. Women with BMI ≥25 kg/m2 had significantly greater risks of recurrence and distant metastasis than those with BMI <25 kg/m2, irrespective of blood glucose. The increased risks remained invariant over a median follow-up of 9.5 years. Mediation analysis indicated that glucose and BMI had independent effects on breast cancer prognosis. Peridiagnostic high fasting glucose and obesity predict worsened short- and long-term outcomes in breast cancer patients. Maintaining healthy blood glucose levels and normal weight may improve prognosis.

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Section: Methodsmentioning

confidence: 99%

Fasting blood glucose and long-term prognosis of non-metastatic breast cancer: a cohort study

Contiero

Berrino

Tagliabue

et al. 2013

Breast Cancer Res Treat

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“…The Birth Defect Registry uses the proven Open Registry software [12-16] to generate cases. The steps in this procedure are as follows:…”

Section: Methodsmentioning

confidence: 99%

Descriptive epidemiology of selected birth defects, areas of Lombardy, Italy, 1999

Tagliabue

Tessandori

Caramaschi³

et al. 2007

Popul Health Metrics

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Background: Birth defects are a leading cause of neonatal and infant mortality in Italy, however little is known of the etiology of most defects. Improvements in diagnosis have revealed increasing numbers of clinically insignificant defects, while improvements in treatment have increased the survival of those with more serious and complex defects. For etiological studies, prevention, and management, it is important to have population-based monitoring which provides reliable data on the prevalence at birth of such defects.

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“…Strengths of the present study are its prospective design, availability of information on diet, availability of ER, PR and HER2 status of the cancers in most cases, and availability of abundant additional information making it possible to adjust for potential confounders including smoking. Furthermore breast cancer cases were identified by the local cancer registry, and it is unlikely that any cases were lost . Other strengths are the large number of food samples used for the analytical determinations of cadmium, collected from local groceries and supermarkets in order to mimic the real sources of foodstuffs in the population …”

Section: Discussionmentioning

confidence: 99%

Dietary cadmium and risk of breast cancer subtypes defined by hormone receptor status: A prospective cohort study

Grioni

Agnoli

Krogh

et al. 2019

Intl Journal of Cancer

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Diet is the primary source of cadmium-a proven Group 1 human carcinogen-for non-smokers. Observational studies investigating the effect of cadmium from food sources on breast cancer risk have produced inconsistent results. We examined the association between dietary cadmium and risk of breast cancer defined by estrogen receptor (ER), progesterone receptor (PR) and HER2 status, in 8924 women recruited to a prospective study between 1987 and 1992. Dietary cadmium intake was estimated using a semi-quantitative food frequency questionnaire at baseline. During a median of 22 years of follow-up, 451 incident cases of breast cancer were identified through the Varese Cancer Registry. Multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for breast cancer and receptor-defined breast cancer subtypes were estimated for quintiles of dietary cadmium intake, adjusting for confounding factors. Mean dietary cadmium intake was 7.8 (standard deviation 1.4) μg/day. Women with highest quintile of cadmium intake had a greater risk of breast cancer (HR 1.54; 95% CI, 1.06-2.22; p trend = 0.028) than those with lowest quintile of intake. Women premenopausal at recruitment had HR = 1.73 (95% CI, 1.10-2.71, highest vs. lowest quintile); postmenopausal women had HR = 1.32 (95% CI, 1.05-1.66 for each standard deviation increase in cadmium). Cadmium-related risk of breast cancer did not vary with ER, PR or HER2 status (p-heterogeneity not significant). These findings support the hypothesis that dietary cadmium is a risk factor for breast cancer.

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Consistency and accuracy of diagnostic cancer codes generated by automated registration: comparison with manual registration

Cited by 15 publications

References 15 publications

Fasting blood glucose and long-term prognosis of non-metastatic breast cancer: a cohort study

Fasting blood glucose and long-term prognosis of non-metastatic breast cancer: a cohort study

Descriptive epidemiology of selected birth defects, areas of Lombardy, Italy, 1999

Dietary cadmium and risk of breast cancer subtypes defined by hormone receptor status: A prospective cohort study

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