Consistency between the endoscopic Kyoto classification and pathological updated Sydney system for gastritis: A cross‐sectional study

Toyoshima, Osamu; Nishizawa, Toshihiro; Yoshida, Shuntaro; Matsuno, Tatsuya; Odawara, Nariaki; Toyoshima, Akira; Sakitani, Kosuke; Watanabe, Hidenobu; Fujishiro, Mitsuhiro; Suzuki, Hidekazu

doi:10.1111/jgh.15693

Cited by 22 publications

(15 citation statements)

References 44 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tissue sections were stained with hematoxylin and eosin to assess activity, inflammation, atrophy, and intestinal metaplasia ( Figure 1 ), and graded on a scale of 0, 1, 2, and 3, corresponding to none, mild, moderate, and severe, respectively, accordingly to the updated Sydney system ( Toyoshima et al, 2022 ). Hp colonization in the stomach was measured using Giemsa staining.…”

Section: Methodsmentioning

confidence: 99%

Decreased xCT activity in patients associated with Helicobacter pylori infection

Liu

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Objective: In animals, Helicobacter pylori (Hp)-induced gastric injury is accompanied by a decrease in the activity of the cysteine/glutamate transporter (xCT), which regulates extracellular glutamate levels. However, the impact of xCT activity in patients with Hp infection remains unclear. This study aims to investigate variations of xCT activity in the gastric mucosa of patients with Hp infection and to provide a clinical basis for identifying targets related to Hp infection.Methods: Our study included a total of 67 patients with gastritis, which consisted of 44 Hp-negative and 23 Hp-positive peptic ulcer cases. The inclusion criteria used to select patients were as follows: gastric histology was determined with a gastroscope, antral biopsies were taken for urease tests, and pathology and culture were performed for analysis of Hp-colonization. The clinical characteristics of the patients were obtained, the expressions of microRNAs and xCT protein were detected using immune histochemical analysis, and the concentration of glutamate in their gastric secretion was determined.Results: The findings revealed that xCT expression was significantly lower in Hp-positive patients as compared to Hp-negative individuals, which was accompanied by a decrease in glutamate concentration in gastric juice. We also discovered a high expression of microRNAs that have been shown to negatively regulate xCT expression, in Hp-positive patients.Conclusion: Reduced xCT activity in patients may play an important role in gastric ulcers caused by Hp infection. Our findings suggest that the microRNA/xCT pathway could be a potential treatment target for Hp-infection-related ulcers.

show abstract

Section: Methodsmentioning

confidence: 99%

Decreased xCT activity in patients associated with Helicobacter pylori infection

Liu

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…All five Kyoto scores were associated with histological inflammation, namely the USS score for neutrophil and mononuclear cell infiltration, which is an indicator of H. pylori infection. The Kyoto atrophy and IM scores correlated with both histological atrophy and IM in the corpus[ 34 , 36 ]. Among H. pylori -infected patients, the Kyoto EF, nodularity, and DR scores indicated histologically high inflammation in the corpus[ 36 - 38 ].…”

Section: Histological Consistency Of Kyoto Classificationmentioning

confidence: 99%

“…The Kyoto atrophy and IM scores correlated with both histological atrophy and IM in the corpus[ 34 , 36 ]. Among H. pylori -infected patients, the Kyoto EF, nodularity, and DR scores indicated histologically high inflammation in the corpus[ 36 - 38 ]. In summary, the Kyoto atrophy and IM scores were concordant with histological corpus atrophy and IM scores.…”

Section: Histological Consistency Of Kyoto Classificationmentioning

confidence: 99%

Kyoto classification of gastritis: Advances and future perspectives in endoscopic diagnosis of gastritis

Toyoshima¹,

Nishizawa²

2022

World J Gastroenterol

Self Cite

View full text Add to dashboard Cite

This editorial provides an update of the recent evidence on the endoscopy-based Kyoto classification of gastritis, clarifying the shortcomings of the Kyoto classification, and providing prospects for future research, with particular focus on the histological subtypes of gastric cancer (GC) and Helicobacter pylori ( H. pylori ) infection status. The total Kyoto score is designed to express GC risk on a score ranging from 0 to 8, based on the following five endoscopic findings: Atrophy, intestinal metaplasia (IM), enlarged folds (EF), nodularity, and diffuse redness (DR). The total Kyoto score reflects H. pylori status as follows: 0, ≥ 2, and ≥ 4 indicate a normal stomach, H. pylori -infected gastritis, and gastritis at risk for GC, respectively. Regular arrangement of collecting venules (RAC) predicts non-infection; EF, nodularity, and DR predict current infection; map-like redness (MLR) predicts past infection; and atrophy and IM predict current or past infection. Atrophy, IM, and EF all increase the incidence of H. pylori -infected GC. MLR is a specific risk factor for H. pylori -eradicated GC, while RAC results in less GC. Diffuse-type GC can be induced by active inflammation, which presents as EF, nodularity, and atrophy on endoscopy, as well as neutrophil and mononuclear cell infiltration on histology. In contrast, intestinal-type GC develops via atrophy and IM, and is consistent between endoscopy and histology. However, this GC risk-scoring design needs to be improved.

show abstract

“…However, advancements in endoscopic technology have allowed for image-enhanced scoping to improve the accuracy of endoscopic evaluation [ 19 , 80 ]. There is one scoring system currently in use called the Kyoto classification [ 81 ] that is used to evaluate active H. pylori infection and risk of gastric cancer. It consists of five endoscopic findings (atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness), cumulating in a score ranging from 0 to 8.…”

Section: Evaluation and Managementmentioning

confidence: 99%

“…A Kyoto score ≥2 indicates H. pylori infection, whereas a score ≥4 suggests gastric cancer risk [ 80 ]. Whereas a few studies have supported the accuracy of the Kyoto classification in diagnosing active H. pylori infection [ 81 , 82 ], endoscopy is rarely the only diagnostic technique used to evaluate Hp infection. Instead, it is almost always paired with biopsies or alternative tests.…”

Section: Evaluation and Managementmentioning

confidence: 99%

Current and Future Perspectives in the Diagnosis and Management of Helicobacter pylori Infection

Shatila

Thomas

2022

JCM

View full text Add to dashboard Cite

Helicobacter pylori (Hp) is a prevalent organism infecting almost half the global population. It is a significant concern, given its associated risk of gastric cancer, which is the third leading cause of cancer death globally. Infection can be asymptomatic or present with dyspeptic symptoms. It may also present with alarm symptoms in the case of progression to cancer. Diagnosis can be achieved non-invasively (breath tests, stool studies, or serology) or invasively (rapid urease test, biopsy, or culture). Treatment involves acid suppression and regimens containing several antibiotics and is guided by resistance rates. Eradication is essential, as it lowers the risk of complications and progression to cancer. Follow-up after eradication is similarly important, as the risk of cancer progression remains. There have been many recent advances in both diagnosis and treatment of Hp. In particular, biosensors may be effective diagnostic tools, and nanotechnology, vaccines, and potassium-competitive acid blockers may prove effective in enhancing eradication rates.

show abstract

Consistency between the endoscopic Kyoto classification and pathological updated Sydney system for gastritis: A cross‐sectional study

Abstract: are responsible for the critical review and final manuscript approval; Hidenobu Watanabe is responsible for pathological diagnosis, critical review, and final manuscript approval. Financial support: There is no funding declaration.

Cited by 22 publications

References 44 publications

Decreased xCT activity in patients associated with Helicobacter pylori infection

Decreased xCT activity in patients associated with Helicobacter pylori infection

Kyoto classification of gastritis: Advances and future perspectives in endoscopic diagnosis of gastritis

Current and Future Perspectives in the Diagnosis and Management of Helicobacter pylori Infection

Contact Info

Product

Resources

About