Consistency of Bruch Membrane Opening Detection as Determined by Optical Coherence Tomography

Hwang, Young Hoon; Kim, Min K.; Ahn, S.H.

doi:10.1097/ijg.0000000000000448

Cited by 15 publications

(33 citation statements)

References 14 publications

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“… 28 In addition, Bruch's membrane may be absent in the area of peripapillary atrophy or might have decreased reflectivity in glaucoma and automated algorithms might no longer detect the BMO accurately. 29 – 31 All OCT images were reviewed by two of the authors (KNM and FS) to ensure proper segmentation of ILM and BMO, and hence, accurate BMO-MRW measurements. Almobarak and colleagues 30 compared the measurement error with automatic versus manual segmentation of ILM and BMO, and reported a median (IQR) difference in BMO-MRW measurement of 12.1 (10.1, 16.8) and 13.4 (10.6, 16.8) μm in healthy and glaucomatous subjects, respectively; neither was statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Structure-Function Relationships in Perimetric Glaucoma: Comparison of Minimum-Rim Width and Retinal Nerve Fiber Layer Parameters

Amini

Daneshvar

Sharifipour

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PurposeTo test the hypotheses that: (1) structure–function (SF) relationships between visual fields (VF) and Bruch's membrane opening-based minimum rim width (BMO-MRW) measurements are superior to those for peripapillary retinal nerve fiber layer (pRNFL) in perimetric glaucoma; (2) BMO-MRW measurements may extend the utility of structural measurement across the range of glaucoma severity; and (3) to estimate the influence of Bruch's membrane opening (BMO) size on BMO-MRW measurements.MethodsOne hundred eight perimetric glaucoma eyes (68 patients) with good quality spectral-domain optical coherence tomography images of the optic disc and pRNFL, and reliable VF within 6 months were recruited. Relationship of global and sectoral BMO-MRW and pRNFL thickness with corresponding VF parameters and the influence of normalizing BMO-MRW (on BMO circumference, nBMO-MRW) on SF relationships were investigated. Broken-stick models were used to compare the point at which pRNFL and BMO-MRW parameters reached their measurement floor.ResultsThe median (interquartile range) of VF mean deviation was −5.9 (−12.6 to −3.6) dB. Spearman correlation coefficients between pRNFL, BMO-MRW, and nBMO-MRW measures and corresponding VF cluster average deviations ranged between 0.55 to 0.80, 0.35 to 0.66, and 0.38 to 0.65, respectively. Bruch's membrane opening–MRW parameters demonstrated weaker SF relationships compared with pRNFL globally and in temporal, temporal-superior, and nasal-inferior sectors (P < 0.03). Normalization of BMO-MRW did not significantly influence SF relationships.ConclusionsStructure–function relationships were somewhat weaker with BMO-MRW parameters compared with pRNFL in eyes with perimetric glaucoma. Bruch's membrane opening–MRW normalization did not significantly change SF relationships in this group of eyes with mild departures from average BMO size.

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Section: Discussionmentioning

confidence: 99%

Structure-Function Relationships in Perimetric Glaucoma: Comparison of Minimum-Rim Width and Retinal Nerve Fiber Layer Parameters

Amini

Daneshvar

Sharifipour

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…Among these eyes, those that underwent at least four RNFL and GCIPL OCT examinations between January 2010 and May 2017 were included. For OCT, only images with signal strengths ≥ 6 (range, 0–10), no segmentation error, no motion artefact and appropriate centration were included . Eyes that underwent ocular surgery or laser treatment during the follow‐up period were not included.…”

Section: Methodsmentioning

confidence: 99%

Glaucomatous progression in the retinal nerve fibre and retinal ganglion cell‐inner plexiform layers determined using optical coherence tomography‐guided progression analysis

Hwang

Kim

Chung

et al. 2018

Clinical and Experimental Optometry

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“…Therefore, a large number of images can be visualised at a glance. Previous studies have reported that RNFLD detection or progression assessment using an RNFL deviation map or sector map is affected by various factors, such as refractive error, RNFLD width, head tilt during the test or optic nerve head centre change . In contrast, GPA compares RNFL thickness maps that are automatically aligned to the baseline image.…”

Section: Discussionmentioning

confidence: 99%

Detection of progression of glaucomatous retinal nerve fibre layer defects using optical coherence tomography‐guided progression analysis

Hwang

Kim

et al. 2018

Clinical and Experimental Optometry

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Purpose: The aim was to investigate the agreement for detection of progression of glaucomatous retinal nerve fibre layer defects (RNFLD) between optical coherence tomographyguided progression analysis (OCT GPA) and conventional red-free fundus photography. Methods: Four hundred and fifteen glaucomatous eyes that underwent at least four serial red-free photographic and OCT examinations were included in the study. Based on the inspection of the red-free fundus photographs and GPA maps, RNFLD progression was defined as the development of a new defect, widening or deepening of a pre-existing RNFLD in red-free fundus photography (photographic progression) or 'Likely Loss' on a GPA map (GPA progression). The agreement of photographic and OCT GPA progression and the factors influencing it, including refractive error, severity of glaucoma (mean deviation of the visual field), type of RNFLD (localised versus diffuse), width of the baseline RNFLD, type of RNFLD progression (new defect, widening, deepening) and location of RNFLD progression (clock-hour sector) were assessed. Results: Among the 415 eyes, 82 (19.8 per cent) showed photographic or GPA progression. Among the 82 eyes with progression, progression was detected only in red-free fundus photography in nine (11.0 per cent) eyes and only in GPA in 32 (39.0 per cent) eyes. In 41 eyes (50.0 per cent), progression was detected with both methods. Detection of RNFLD progression only in GPA was associated with a higher myopia, diffuse RNFLD, deepening of the RNFLD and RNFLD progression at the 6, 9 and 12 o'clock positions (p < 0.05). Conclusions: OCT GPA may be a useful supplement to conventional red-free fundus photography for detecting RNFLD progression.

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Consistency of Bruch Membrane Opening Detection as Determined by Optical Coherence Tomography

Cited by 15 publications

References 14 publications

Structure-Function Relationships in Perimetric Glaucoma: Comparison of Minimum-Rim Width and Retinal Nerve Fiber Layer Parameters

Structure-Function Relationships in Perimetric Glaucoma: Comparison of Minimum-Rim Width and Retinal Nerve Fiber Layer Parameters

Glaucomatous progression in the retinal nerve fibre and retinal ganglion cell‐inner plexiform layers determined using optical coherence tomography‐guided progression analysis

Detection of progression of glaucomatous retinal nerve fibre layer defects using optical coherence tomography‐guided progression analysis

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