Consistency of quantitative analysis of coronary computed tomography angiography

Lee, Sang Eun; Park, Hyung Bok; Xuan, Dongchun; Lee, Byoung Kwon; Hong, Myeong Ki; Jang, Yangsoo; Chang, Hyuk Jae

doi:10.1016/j.jcct.2018.09.012

Cited by 27 publications

(16 citation statements)

References 17 publications

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“…34,35 However, we adjusted the baseline CACS and PV and the difference in vendors and tube voltages between two CCTA scans in the multivariate analysis and tested the consistency of CCTA in quantitative compositional PV assessment to ensure the reliability and reproducibility of CCTA parameters (see Supplementary data online, Figures S2 and S3). 36 Moreover, because no consensus on the use of serial CCTA for CAD monitoring currently exists, 6 an observational study such as the PARADIGM study provides a unique opportunity to evaluate the correlation between CACS progression assessed by CAC scans and the change in plaque burden. Second, we could not stratify the association between CACS and PV according to the intensity of statin treatment.…”

Section: Discussionmentioning

confidence: 99%

Differential association between the progression of coronary artery calcium score and coronary plaque volume progression according to statins: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging (PARADIGM) study

Lee

Sung

Andreini

et al. 2019

European Heart Journal - Cardiovascular Imaging

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Aims Coronary artery calcium score (CACS) is a strong predictor of major adverse cardiac events (MACE). Conversely, statins, which markedly reduce MACE risk, increase CACS. We explored whether CACS progression represents compositional plaque volume (PV) progression differently according to statin use. Methods and results From a prospective multinational registry of consecutive patients (n = 2252) who underwent serial coronary computed tomography angiography (CCTA) at a ≥ 2-year interval, 654 patients (61 ± 10 years, 56% men, inter-scan interval 3.9 ± 1.5 years) with information regarding the use of statins and having a serial CACS were included. Patients were divided into non-statin (n = 246) and statin-taking (n = 408) groups. Coronary PVs (total, calcified, and non-calcified; sum of fibrous, fibro-fatty, and lipid-rich) were quantitatively analysed, and CACS was measured from both CCTAs. Multivariate linear regression models were constructed for both statin-taking and non-statin group to assess the association between compositional PV change and change in CACS. In multivariate linear regression analysis, in the non-statin group, CACS increase was positively associated with both non-calcified (β = 0.369, P = 0.004) and calcified PV increase (β = 1.579, P < 0.001). However, in the statin-taking group, CACS increase was positively associated with calcified PV change (β = 0.756, P < 0.001) but was negatively associated with non-calcified PV change (β = −0.194, P = 0.026). Conclusion In the non-statin group, CACS progression indicates the progression of both non-calcified and calcified PV progression. However, under the effect of statins, CACS progression indicates only calcified PV progression, but not non-calcified PV progression. Thus, the result of serial CACS should be differently interpreted according to the use of statins.

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Section: Discussionmentioning

confidence: 99%

Differential association between the progression of coronary artery calcium score and coronary plaque volume progression according to statins: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging (PARADIGM) study

Lee

Sung

Andreini

et al. 2019

European Heart Journal - Cardiovascular Imaging

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“… 1 , 2 , 3 , 4 In addition, the development and progression of coronary atherosclerotic plaque across the entire coronary tree can be evaluated using serial coronary CT angiography scans. 5 , 6 Serial assessment of coronary artery plaques through coronary CT angiography provides clinical information regarding the progression of disease and the risk of experiencing future adverse cardiovascular events. 7 , 8 …”

Section: Introductionmentioning

confidence: 99%

Association of Cardiovascular Disease Risk Factor Burden With Progression of Coronary Atherosclerosis Assessed by Serial Coronary Computed Tomographic Angiography

et al. 2020

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Key Points Question Is the risk factor burden of cardiovascular disease, as assessed by atherosclerotic cardiovascular disease risk score, associated with coronary plaque progression and the development of adverse plaque characteristics? Findings In this cohort study of 1005 adult patients from an international multicenter registry who underwent serial coronary computed tomographic angiography, the progression of coronary atherosclerotic plaque volume and the development of adverse plaque characteristics was greater in patients with a high atherosclerotic cardiovascular disease risk score. Meaning The study findings suggest that the overall cardiovascular disease risk burden is associated with the progression of coronary atherosclerosis; the progression of fibrofatty plaque and low-attenuation plaque and the development of adverse plaque characteristics appear to be accelerated in patients with a high risk of atherosclerotic cardiovascular disease.

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“…The next factor -the artery direction -is a vector joining central points of the artery plane calculated in 3D as their linear approximation (the least squares criterion). Angle changes are detected by comparing 2 consecutive directions for 2 given segments of the artery, t 1, and t 2 , and the rotation angle is defined as: Finally, the EF, which is the ratio of the major (marked as 2a) to the minor (marked as 2b) axes of the ellipsoidal artery plane, is calculated: (5) In contrast to healthy arteries, the tortuous ones lack vertical planes on the CTA images, yielding high EF ratios (see Figure 1 for angle and EF measurements).…”

Section: Methodsmentioning

confidence: 99%

The next level of preoperative arteries computed tomography angiography

Dziekiewicz¹,

Markiewicz²

2021

Kardiol Pol

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Consistency of quantitative analysis of coronary computed tomography angiography

Cited by 27 publications

References 17 publications

Differential association between the progression of coronary artery calcium score and coronary plaque volume progression according to statins: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging (PARADIGM) study

Differential association between the progression of coronary artery calcium score and coronary plaque volume progression according to statins: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging (PARADIGM) study

Association of Cardiovascular Disease Risk Factor Burden With Progression of Coronary Atherosclerosis Assessed by Serial Coronary Computed Tomographic Angiography

The next level of preoperative arteries computed tomography angiography

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