Consistency of trajectories of suicidal ideation and depression symptoms: Evidence from a randomized controlled trial

Batterham, Philip J.; Spijker, Bregje A. J. van; Mackinnon, Andrew; Calear, Alison L.; Wong, Quincy J. J.; Christensen, Helen

doi:10.1002/da.22863

Cited by 52 publications

(39 citation statements)

References 54 publications

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“…However, many who ultimately die by suicide have not received mental health care in their last year (e.g., Miller & Druss, 2001), limiting the impact clinical interventions for suicide can have. Further, suicide is the result of a variety of biological, genetic, social, cultural, psychological, and behavioral factors, which are not all addressed by clinical interventions (e.g., Batterham et al, 2019; De Leo, 2004; Iyengar et al, 2018; Michel et al, 2017; Qin et al, 2003; Turecki et al, 2019). As such, suicide prevention requires public health approaches to reduce risk in the whole population (Caine, 2013; David‐Ferdon et al, 2016; Goldsmith et al, 2002; Knox et al, 2004; Roof et al, 2016; Sanddal et al, 2003; U.S. Public Health Service, 1999; 2001; Yip, 2011).…”

Section: Introductionmentioning

confidence: 99%

Veterans' satisfaction and perspectives on helpfulness of the Veterans Crisis Line

Johnson

Muehler

Stacy

2021

Suicide & Life Threat Behav

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Objective Crisis hotlines are an important part of a public health approach to suicide prevention. The Veterans Crisis Line (VCL) provides hotline services to Veterans. There is a paucity of research concerning the effectiveness of the VCL. The current work describes efforts to establish groundwork for VCL effectiveness research. Methods 155 VCL users who were referred to a Veterans Affairs Medical Center Suicide Prevention Team completed interviews including open‐ended and closed‐ended questions. Outcomes are reported for suicidal participants, non‐suicidal participants, and those who had emergency intervention. Thematic analysis was used for open‐ended questions. Results Eighty‐seven percent of interviewees expressed satisfaction with the VCL, 81.9% reported that the VCL was helpful, and 72.9% said that the VCL helped keep them safe. Of those with suicidal thoughts, 82.6% said the contact helped stop them from killing themselves. Themes are described concerning user identified reasons for VCL contact, most and least helpful aspects of the contact, and suggestions for improvement. Discussion This project demonstrates that this group of people who used the VCL overwhelmingly finds the service to be helpful and a barrier to suicide. Further, implications of user feedback for application to VCL operations and future research are discussed.

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Section: Introductionmentioning

confidence: 99%

Veterans' satisfaction and perspectives on helpfulness of the Veterans Crisis Line

Johnson

Muehler

Stacy

2021

Suicide & Life Threat Behav

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“…In a cohort of depressed outpatients, Batterham et al have identified different types of trajectories of SI and depressive symptoms. The characteristics of class membership were different for the two outcomes (Batterham et al, 2019). Some factors could thus impact changes of SI independently of depression.…”

Section: Introductionmentioning

confidence: 99%

Characterization of depressed bipolar patients with current suicidal ideation

Nobile

Dubois

Aouizerate

et al. 2020

Aust N Z J Psychiatry

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Objective: Bipolar disorder is one of the most frequent psychiatric disorders among suicidal patients. A large part of patients with bipolar disorder (30–50%) will attempt suicide. Suicidal ideation being a major risk factor of suicidal act, it is crucial to better characterize patients with suicidal bipolar depression (i.e. depression with current suicidal ideation). The aim of this study was to characterize suicidal bipolar depressed patients in comparison with non-suicidal depressed patients in terms of clinical characteristics, evolution of depression and suicidal ideation course over time, and risk of suicide attempt during follow-up. Methods: Among patients with bipolar disorder recruited from the network of FondaMental expert centres for bipolar disorder between 2009 and 2017, we selected patients with at least mild depression (Montgomery–Åsberg Depression Rating Scale total score >11) and without current manic symptomatology (Young Mania Rating Scale total score <7) at baseline ( N = 938). Suicidal depression was defined by a baseline score ⩾2 for item 12 of the Quick Inventory of Depressive Symptomatology–Self Report ( N = 271, 28.9%). Non-suicidal depression was defined by a baseline item 12 of the Quick Inventory of Depressive Symptomatology–Self Report score <2 ( N = 667, 71.1%). A subsample of about 300 patients (with or without suicidal ideation at baseline) was followed up for 2 years. Results: Baseline clinical features (e.g. depression severity, childhood trauma, global functioning) were more severe in patients with than without suicidal depression. Suicidal patients tended to remain more suicidal throughout the follow-up than patients without suicidal ideation at baseline (3.4-fold higher risk of persistent suicidal ideation at the 2-year visit despite an improvement in depressive symptomatology). Conclusions: Depressed bipolar disorder patients reporting suicidal ideation had more severe clinical features at baseline and were more prone to report persistent suicidal ideation during the follow-up, independently of thymic state. Clinicians should closely monitor this subgroup of patients.

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“…For instance, among individuals with treatment-resistant MDD, a recent randomized placebo-controlled trial showed large decreases in depressive symptoms 1, 2, and 7 days administration of ayahuasca (Palhano-Fontes et al, 2019). However, extant research suggests that suicidality can occur independent from depressive symptoms (Brent et al, 2005; Brent, 2010; Brent and Mann, 2010; Dutta et al, 2017; Batterham et al, 2019) and decreases in depressive symptoms are not always associated with decreases in suicidality (Christensen et al, 2013). For instance, compared with placebo, even first-line interventions for depression (i.e., selective serotonin reuptake inhibitors; SSRIs) lead to limited to no decreases in suicidality (intent to treat ES = –0.04–0.20; Näslund et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial

et al. 2019

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Suicide is a major public health problem. Given increasing suicide rates and limitations surrounding current interventions, there is an urgent need for innovative interventions for suicidality. Although ayahuasca has been shown to target mental health concerns associated with suicidality (i.e., depression and hopelessness), research has not yet explored the impact of ayahuasca on suicidality. Therefore, we conducted secondary analyses of a randomized placebo-controlled trial in which individuals with treatment-resistant depression were administered one dose of ayahuasca (n = 14) or placebo (n = 15). Suicidality was assessed by a trained psychiatrist at baseline, as well as 1 day, 2 days, and 7 days after the intervention. A fixed-effects linear mixed model, as well as between and within-groups Cohen's d effect sizes were used to examine changes in suicidality. Controlling for baseline suicidality, we found a significant effect for time (p < .05). The effect of the intervention (i.e., ayahuasca vs. placebo) trended toward significance (p = .088). At all time points, we found medium between-group effect sizes (i.e., ayahuasca vs. placebo; day 1 Cohen’s d = 0.58; day 2 d = 0.56; day 7 d = 0.67), as well as large within-group (ayahuasca; day 1 Cohen's d = 1.33; day 2 d = 1.42; day 7 d = 1.19) effect sizes, for decreases in suicidality. Conclusions: This research is the first to explore the impact of ayahuasca on suicidality. The findings suggest that ayahuasca may show potential as an intervention for suicidality. We highlight important limitations of the study, potential mechanisms, and future directions for research on ayahuasca as an intervention for suicidality. Clinical Trial Registration: , identifier NCT02914769.

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Consistency of trajectories of suicidal ideation and depression symptoms: Evidence from a randomized controlled trial

Cited by 52 publications

References 54 publications

Veterans' satisfaction and perspectives on helpfulness of the Veterans Crisis Line

Veterans' satisfaction and perspectives on helpfulness of the Veterans Crisis Line

Characterization of depressed bipolar patients with current suicidal ideation

The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial

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