2018
DOI: 10.1016/j.resuscitation.2018.04.009
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Consistent head up cardiopulmonary resuscitation haemodynamics are observed across porcine and human cadaver translational models

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Cited by 34 publications
(40 citation statements)
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“…Next, we excluded 27 articles (because they were review articles, not original studies, or posts/conference abstracts, studied human cadavers, not compare with supine position, lacked detailed data, letter to editor or post CPR). Initially, eight studies [ 14 18 , 21 , 22 , 28 ], including 147 pigs, were included; however, we excluded one study (that used different CPR methods with different angles) because of the lack of a comparison group [ 21 ]. Therefore, 7 studies with 131 subjects were ultimately analyzed in the meta-analysis (Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…Next, we excluded 27 articles (because they were review articles, not original studies, or posts/conference abstracts, studied human cadavers, not compare with supine position, lacked detailed data, letter to editor or post CPR). Initially, eight studies [ 14 18 , 21 , 22 , 28 ], including 147 pigs, were included; however, we excluded one study (that used different CPR methods with different angles) because of the lack of a comparison group [ 21 ]. Therefore, 7 studies with 131 subjects were ultimately analyzed in the meta-analysis (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…In recent years, animal studies have revealed the head-up positions (HUP) with ACD + ITD CPR or automated (LUCAS 2.0) + ITD CPR could decrease ICP and improve CerPP [ 14 ] and that it may even improve coronary perfusion pressure (CoPP) [ 15 ] in animal experiments. As to HUP, some studies tilted whole body up, also called “the reverse-Trendelenburg position,” to lower ICP.…”
Section: Introductionmentioning
confidence: 99%
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“…Human beings have much larger lower extremities, and other anatomical differences may alter the physiology of head-up/torso-up CPR. Accordingly, we recently compared the swine model with a cadaver model with this bundled flow augmenting approach and found similar proportional changes in blood flow (32). These findings encourage us to believe that this distinction is less of a concern, but the optimal degree of elevation (e.g., 20° vs 30°) and the actual elevation sequence and timing of elevation for human beings are all important considerations that are currently under evaluation using new technology to support the degree and timing of the head-up/torso-up implementation (33).…”
Section: Discussionmentioning
confidence: 92%
“…In a swine study, CerPP remained significantly higher in the HUP-CPR pigs, especially when an impedance threshold device was used [47]. These physiological changes were recently replicated in deceased human cadaver models; HUP-CPR resulted in decreased ICP and increased CerPP, further supporting its use in patients in cardiac arrest [48]. Nevertheless, the compression-related cardiac output may be impaired during human HUP-CPR due to pooling of blood in the lower extremities.…”
Section: Neuroprotection During Cardiopulmonary Resuscitation: Brain mentioning
confidence: 88%