Consistent neuroanatomical age-related volume differences across multiple samples

Walhovd, Kristine B.; Westlye, Lars T.; Amlien, Inge K.; Espeseth, Thomas; Reinvang, Ivar; Raz, Naftali; Agartz, Ingrid; Salat, David H.; Greve, Doug; Fischl, Bruce; Dale, Anders M.; Fjell, Anders M.

doi:10.1016/j.neurobiolaging.2009.05.013

Cited by 473 publications

(485 citation statements)

References 77 publications

(188 reference statements)

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“…This is in contrast to a substantial number of MRI studies reporting a reliable age-related decline in hippocampal volume in healthy humans (Kaye et al 1997;Mueller et al 1998;Tisserand et al 2000;Raz et al 2004;Walhovd et al 2009). While total hippocampal volume is unaltered with age in rhesus monkeys, it correlates with DR acquisition and average accuracy (Shamy et al 2010), consistent with literature suggesting that the hippocampus modulates working memory (Friedman and Goldman-Rakic 1988;Eberling et al 1997).…”

Section: Gross Anatomy Of Hippocampal and Related Cortical Regionscontrasting

confidence: 85%

Neuronal and morphological bases of cognitive decline in aged rhesus monkeys

Hara

Rapp

Morrison

2011

AGE

121

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Rhesus monkeys provide a valuable model for studying the basis of cognitive aging because they are vulnerable to age-related decline in executive function and memory in a manner similar to humans. Some of the behavioral tasks sensitive to the effects of aging are the delayed response working memory test, recognition memory tests including the delayed nonmatching-to-sample and the delayed recognition span task, and tests of executive function including reversal learning and conceptual set-shifting task. Much effort has been directed toward discovering the neurobiological parameters that are coupled to individual differences in age-related cognitive decline. Area 46 of the dorsolateral prefrontal cortex (dlPFC) has been extensively studied for its critical role in executive function while the hippocampus and related cortical regions have been a major target of research for memory function. Some of the key age-related changes in area 46 include decreases in volume, microcolumn strength, synapse density, and α1-and α2-adrenergic receptor binding densities. All of these measures significantly correlate with cognitive scores. Interestingly, the critical synaptic subtypes associated with cognitive function appear to be different between the dlPFC and the hippocampus. For example, the dendritic spine subtype most critical to task acquisition and vulnerable to aging in area 46 is the thin spine, whereas in the dentate gyrus, the density of AGE (2012) large mushroom spines with perforated synapses correlates with memory performance. This review summarizes age-related changes in anatomical, neuronal, and synaptic parameters within brain areas implicated in cognition and whether these changes are associated with cognitive decline.

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Section: Gross Anatomy Of Hippocampal and Related Cortical Regionscontrasting

confidence: 85%

Neuronal and morphological bases of cognitive decline in aged rhesus monkeys

Hara

Rapp

Morrison

2011

AGE

121

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“…In both studies, ventricular size returned to baseline with 7 days of recovery. Enlargement of the lateral ventricles, observed in normal aging (Pfefferbaum et al, 1994;Walhovd et al, 2011), and many pathologies including traumatic brain injury (Bigler and Maxwell, 2011), Alzheimer's disease (Fox and Schott, 2004), and schizophrenia (Sayo et al, 2012), is often interpreted as a marker of atrophy (ie, cell loss) of the surrounding brain regions. In the current study, however, measurement of selective brain regions (ie, dorsal and ventral hippocampi, caudate-putamen, thalamus) did not detect volume changes that could explain ventricular expansion.…”

Section: Discussionmentioning

confidence: 99%

A Mechanism of Rapidly Reversible Cerebral Ventricular Enlargement Independent of Tissue Atrophy

Zahr

Mayer

Rohlfing

et al. 2013

Neuropsychopharmacol

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Ventricular enlargement, a common in vivo marker of aging, disease, and insult, is presumed to reflect atrophy of surrounding brain regions. Pathological mechanisms underlying ventricular enlargement, however, are likely specific to the condition under investigation. Here, multimodal imaging, incorporating structural magnetic resonance imaging (MRI), MR spectroscopy (MRS), and diffusion weighted imaging (DWI), was used in rats exposed to binge ethanol (EtOH) to provide insight into a mechanism of reversible ventricular enlargement. During intoxication, MRI revealed expansion of ventricles, but volume changes in dorsal or ventral hippocampi, caudateputamen, or thalamus were not detectible. MRS of whole-brain parenchyma showed decreases in N-acetylasparate (NAA) and tissue water T2, and increases in choline-containing compounds (Cho). DWI showed decreased diffusivity selective to the thalamus. All MR parameters returned to baseline with 7 days of recovery. Rapid recovery of ventricular volume and the absence of detectable tissue volume reductions in brain regions adjacent to ventricles argue against atrophy as a mechanism of ventricular expansion. Decreased tissue water T2 and decreased thalamic diffusivity suggest lower tissue water content and a role for both NAA and Cho, as osmolytes is proposed. Together, these data support a model of fluid redistribution during acute EtOH intoxication and recovery to account for rapid ventricular volume changes.

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“…the role of the naCC in obesity and aging was also demonstrated in humans using magnetic resonance imaging (mRi) that revealed volume changes in overweighed individuals as well as in aging humans [12,19,21,33].…”

mentioning

confidence: 95%

Stability of CART peptide expression in the nucleus accumbens in aging

Armbruszt¹,

Figler²,

Ábrahám³

2015

Acta Biologica Hungarica

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aging is accompanied by changes of several anorexigenic and orexigenic neuropeptides expressed in various brain areas that control food intake and these changes correlate with senescent anorexia. during aging expression of cocaine-and amphetamine-regulated transcript (CaRt) peptide was reported to be reduced in the hypothalamic nuclei related to food intake. although CaRt peptide is abundant in the nucleus accumbens that also plays a crucial role in the food intake regulation, no data is available about the CaRt peptide expression in this region through aging. in the present study, CaRt peptide immunoreactivity was compared in the nucleus accumbens of young adult (4-and 7-month-old) middle-aged (15-month-old) and aging (25-32-month-old) long-evans rats. the density of CaRt-immunoreactive cells and axon terminals in the nucleus accumbens was measured with computer-aided densitometry. CART-immunodensity was similar in the old rats and in the younger animals without significant difference between age groups. in addition, no gender-difference was observed when CaRt-immunoreactivities in the nucleus accumbens of male and female animals were compared. our results indicate that CaRt peptide expression in the nucleus accumbens is stable in adults and does not change with age.

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Consistent neuroanatomical age-related volume differences across multiple samples

Cited by 473 publications

References 77 publications

Neuronal and morphological bases of cognitive decline in aged rhesus monkeys

Neuronal and morphological bases of cognitive decline in aged rhesus monkeys

A Mechanism of Rapidly Reversible Cerebral Ventricular Enlargement Independent of Tissue Atrophy

Stability of CART peptide expression in the nucleus accumbens in aging

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