We perform a multimodel detection and attribution study with climate model simulation output and satellite-based measurements of tropospheric and stratospheric temperature change. We use simulation output from 20 climate models participating in phase 5 of the Coupled Model Intercomparison Project. This multimodel archive provides estimates of the signal pattern in response to combined anthropogenic and natural external forcing (the fingerprint) and the noise of internally generated variability. Using these estimates, we calculate signal-to-noise (S/N) ratios to quantify the strength of the fingerprint in the observations relative to fingerprint strength in natural climate noise. For changes in lower stratospheric temperature between 1979 and 2011, S/N ratios vary from 26 to 36, depending on the choice of observational dataset. In the lower troposphere, the fingerprint strength in observations is smaller, but S/N ratios are still significant at the 1% level or better, and range from three to eight. We find no evidence that these ratios are spuriously inflated by model variability errors. After removing all global mean signals, model fingerprints remain identifiable in 70% of the tests involving tropospheric temperature changes. Despite such agreement in the large-scale features of model and observed geographical patterns of atmospheric temperature change, most models do not replicate the size of the observed changes. On average, the models analyzed underestimate the observed cooling of the lower stratosphere and overestimate the warming of the troposphere. Although the precise causes of such differences are unclear, model biases in lower stratospheric temperature trends are likely to be reduced by more realistic treatment of stratospheric ozone depletion and volcanic aerosol forcing.climate change detection and attribution | climate modeling | multimodel analysis P attern-based fingerprint studies seek to elucidate the complex causes of historical climate change (1-9). An initial focus of fingerprint research was on the vertical structure of atmospheric temperature changes (3,5,7,(10)(11)(12)(13)(14)(15). This work indicated that natural external forcings, such as volcanic eruptions and solar variability, produce atmospheric temperature fingerprints that differ from the fingerprints of human-caused changes in greenhouse gases or aerosols (3,11,16). Fingerprinting with atmospheric temperature changes has provided strong scientific evidence of a discernible human influence on global climate (17)(18)(19).Most fingerprint studies involving atmospheric temperature have relied on individual models, with relatively little consideration of how results are affected by model and observational uncertainty. The key model uncertainties are in the anthropogenic and natural external forcings (20), the climate responses to these forcings, and the estimates of internal variability (17)(18)(19). Uncertainties in observations of atmospheric temperature change arise because of the different choices analysts make in adjusting raw mea...